Nickel-oxide embedded laser-induced graphene for high-performance supercapacitors.

This study explores the fabrication of nickel-oxide-embedded laser-induced graphene and its application in high-performance supercapacitors. Supercapacitors are critical for various applications due to their high power density and long cycle life. Nevertheless, they suffer from lower energy density compared to batteries.

Peripherally Inserted Central Catheters-associated blood stream infections-occurrence, risk factors, and pathogens, a single center study.

Background: Peripherally inserted central catheters (PICCs) are central venous catheters inserted peripherally but terminate in great vessels. PICCs are widely used for patients requiring long-term intravenous therapy in both in-patient and out-patient settings.

Aim: This study was carried out to understand PICC-related complications, specifically infections and causal pathogens, in a tertiary care hospital in Kerala, South India.

Lentiviral vector mediated gene therapy for type I Dent disease ameliorates Dent disease-like phenotypes for three months in ClC-5 null mice.

Type 1 Dent disease is caused by changes in chloride voltage-gated channel 5 () gene on chromosome X, which causes the lack or dysfunction of chloride channel ClC-5. Affected subjects show proteinuria and hypercalciuria, and eventually develop end-stage kidney disease. Currently there is no cure for this disease.

Targeting DNA polymerase to DNA double-strand breaks reduces DNA deletion size and increases templated insertions generated by CRISPR/Cas9.

Most insertions or deletions generated by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) endonucleases are short (<25 bp), but unpredictable on-target long DNA deletions (>500 bp) can be observed. The possibility of generating long on-target DNA deletions poses safety risks to somatic genome editing and makes the outcomes of genome editing less predictable. Methods for generating refined mutations are desirable but currently unavailable.

Artificial Intelligence in hepatology, liver surgery and transplantation: Emerging applications and frontiers of research.

The integration of artificial intelligence (AI) and augmented realities into the medical field is being attempted by various researchers across the globe. As a matter of fact, most of the advanced technologies utilized by medical providers today have been borrowed and extrapolated from other industries. The introduction of AI into the field of hepatology and liver surgery is relatively a recent phenomenon.

Role of nonsurgical periodontal therapy on leptin levels and total antioxidant capacity in chronic generalised periodontitis patients - A clinical trial.

Introduction: Periodontitis causes oxidative stress and reduce total antioxidant levels. The aim of this study was to determine the effect of non-surgical periodontal treatment on leptin levels and total antioxidant capacity in chronic periodontitis.

Materials And Methods: A total of 35 chronic periodontitis (ChP) patients and 35 systemically and periodontal healthy subjects were enrolled in this study.

Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing.

Transient delivery of CRISPR-based genome editing effectors is important to reduce off-target effects and immune responses. Recently extracellular vesicles (EVs) have been explored for Cas9 ribonucleoprotein (RNP) delivery. However, lack of mechanisms to enrich RNPs into EVs limited the efficiency of EVs as a RNP delivery vehicle.

Sensitive and reliable evaluation of single-cut sgRNAs to restore dystrophin by a GFP-reporter assay.

Most Duchenne muscular dystrophy (DMD) cases are caused by deletions or duplications of one or more exons that disrupt the reading frame of DMD mRNA. Restoring the reading frame allows the production of partially functional dystrophin proteins, and result in less severe symptoms. Antisense oligonucleotide mediated exon skipping has been approved for DMD, but this strategy needs repeated treatment.

Transverse Aortic Arch Transection in a Polytrauma Patient-Challenges Faced and Lessons Learned.

Aortic injuries are notoriously lethal, particularly when associated with concomitant injuries. We describe the evaluation and management of a polytrauma patient with transverse arch transection that was complicated by dissection of both common carotid arteries. He was managed with aortic arch replacement and reimplanatation of the innominate and left common carotid arteries with an additional graft from the ascending aorta to the right common carotid artery.

Lower extremity arteries.

Lower extremity arteries play vital role of supplying blood to the extremity bone, muscles, tendons and nerves to maintain the mobility of the body. These arteries may get involved with a number of disease processes which restrict the optimal functioning of the limb. The knowledge of various diseases, clinical presentation, appearance on various imaging modalities and segments of involvement helps one to clinch the diagnosis.

An experimental research in mice on the "soft tissue reaction to 3 different mesh implants: Titanium silk, Parietene Progrip and Prolene".

Purpose: To analyze the soft tissue reaction of 'Titanium Silk' mesh implant in comparison with 'Parietene Progrip' and 'Prolene' mesh implants for the reinforcement and augmentation of soft tissues to improve the results of static correction in Facial Paralysis and other defects of Maxillofacial region.

Materials And Methods: Under standard laboratory conditions, 89 mice were divided into 4 groups: a control group of 5 mice; first group of 28 mice with Titanium mesh implant, second group of 28 mice with semi-resorbable 'Parietene Progrip' implant and third group of 28 mice with 'Prolene' implant. Under inhalational anesthesia with ethyl ether at days 7, 14, 30 and 60, seven mice from each experimental group underwent Gross and histological analysis of the mesh structures for the following characteristics: Macrophage Infiltration, Multinucleated Macrophages, Meshwork around the implant fibers, Connective tissue proliferation, Angiogenesis and Fibroblasts.

Discovery of a diverse set of esterases from hot spring microbial mat and sea sediment metagenomes.

Esterases are an important group of biocatalysts for synthetic organic chemistry. Functional metagenomics allows discovery of novel biocatalysts by providing access to the gene pool of the microbial community of a habitat. Two metagenomic libraries representing the gene pool of sea sediment and hot spring microbial mat were constructed.

Preoperative planning for advanced modelling of anterolateral thigh flaps in the treatment of severe haemifacial atrophy in Parry-Romberg and Goldenhar syndrome.

Background: Technological advancement in medical science is constantly innovating solutions to the varied and complex challenges of surgery. Digital diagnostics and prospective microsurgery are rapidly evolving. Three-dimensional (3-D) imagery and computed tomography (CT) scanning can determine accurate dimensions of many defects.

Hepatic Amyloidosis: Something That Can camouflage and Deceive our Perception!

Amyloidosis is a multi-systemic diffusely infiltrating disease due to extracellular deposition of protein-mucopolysaccharide complexes. The type of protein deposited determines the subgroup of amyloid. Hepatic amyloidosis is a rare infiltrating disease affecting the hepatic parenchyma.

Evaluation of inflammatory markers interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) in asthma.

Introduction: Even though IL-6 and MMP-9 are associated with airway inflammation in asthma, there is paucity of data in Indian population.

Objective: To determine the levels of IL-6 and MMP-9 in the serum of patients suffering from asthma, and correlate with (a) disease severity, as per GINA guidelines; (b) clinical phenotypes; and (c) response to treatment.

Methodology: The levels of IL-6 and MMP-9 were compared between moderate persistent asthma (n = 25), severe persistent asthma (n = 25) and normal controls (n = 30).

First Indian single center experience with pipeline embolization device for complex intracranial aneurysms.

Background: Flow diversion is a novel method of therapy wherein an endoluminal sleeve, the flow diverter stent is placed across the neck of complex aneurysms to curatively reconstruct abnormal vasculature. We present the first Indian single center experience with the pipeline embolization device (PED) and 6 months follow-up results of 5 patients.

Subjects And Methods: Five complex or recurrent intracranial aneurysms in five patients were treated with PED.