Publications by authors named "Manimala Dharmangadan"
Background: Necrotizing fasciitis (NF) is a rare but potentially life-threatening soft tissue infection. The objective of this study was to assess the association between timely surgery within 6 h and hospital mortality in patients with limb NF, and to describe the trends in patients with NF, time to surgery and standardized mortality ratio (SMR) over 11 years.
Methods: This was a multicenter, retrospective cohort study of all intensive care unit patients who had emergency surgery within 24 h of hospitalization for limb NF between April 1, 2008 and March 31, 2019 in Hong Kong.
Background: Sepsis surveillance using electronic health record (EHR)-based data may provide more accurate epidemiologic estimates than administrative data, but experience with this approach to estimate population-level sepsis burden is lacking.
Methods: This was a retrospective cohort study including all adults admitted to publicly-funded hospitals in Hong Kong between 2009-2018. Sepsis was defined as clinical evidence of presumed infection (clinical cultures and treatment with antibiotics) and concurrent acute organ dysfunction (≥2 point increase in baseline SOFA score).
Article Synopsis
- A study compared hospital outcomes between critically ill patients with COVID-19 and those with influenza A, focusing on mortality rates and risk factors.
- The research involved a retrospective analysis of adult patients in Hong Kong, matching 373 COVID-19 patients with 373 influenza A patients based on similar characteristics.
- Findings showed that COVID-19 patients had a significantly higher hospital mortality rate (17.5%) compared to influenza A patients (7.5%), with factors such as age and coinfections impacting these outcomes.
Article Synopsis
- * The research utilized data from a population electronic health record database and found that the APACHE IV standard mortality ratio (SMR) improved significantly, indicating better predictive performance over time as well.
- * Overall, despite limited healthcare resources, Hong Kong's ICU services have become more efficient and of higher quality, with shorter than predicted length of stay for patients.