Publications by authors named "Manikandan Thirunavukkarasu"

Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%-15% of nephrotic syndrome cases are non-responders of steroid treatment (SRNS).

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Seven human-specific Alu markers were studied in 574 unrelated individuals from 10 endogamous groups and 2 hill tribes of Tamil Nadu and Kerala states. DNA was isolated, amplified by PCR-SSP, and subjected to agarose gel electrophoresis, and genotypes were assigned for various Alu loci. Average heterozygosity among caste populations was in the range of 0.

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Article Synopsis
  • Nephrotic syndrome (NS) in children has been linked to genetic factors, specifically HLA alleles, with a study focusing on this relationship in south India.
  • HLA genotyping was conducted on 183 children with NS (76 steroid sensitive and 107 steroid resistant) and 91 healthy controls, finding several significant associations between specific HLA alleles and NS.
  • The study identified strong susceptibility links for alleles DRB1*07 and DQB1*02, while protective associations were noted for DRB1*10 and DQB1*05, emphasizing the complex role of these genetic markers in the disease.
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The aim of this study was to measure the serum concentrations of heat shock protein (HSP) 70 and C-reactive protein (CRP) and the expression levels of the hsp70 gene among frequent users of mobile phones (FUMPs). We enrolled 120 employees of information technology (IT)/IT enabled service companies (FUMPs; IT professionals) and 102 infrequent users of mobile phones (IFUMPs; people from non-IT professions) as controls. The serum concentrations of HSP70 and CRP were measured by enzyme-linked immunosorbant assay and hsp70 gene expression by reverse transcription polymerase chain reaction.

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