Fabrication of bio-mimic nanozyme based on Mxene@AuNPs and molecular imprinted poly(thionine) films for creatinine detection.

Creatinine (Ctn) is a biomarker for chronic kidney disease (CKD). In this study, a highly sensitive and specific detection method for Ctn based on a molecularly imprinted polymer (MIP) based electrochemical biosensor was developed. Mxene (Mx), which has high absorption properties, was modified using carbon screen-printed electrodes (SPCE).

A Novel Ferrocene-Linked Thionine as a Dual Redox Mediator for the Electrochemical Detection of Dopamine and Hydrogen Peroxide.

We introduce a novel dual redox mediator synthesized by covalently linking ferrocene dicarboxylic acid (FcDA) and thionine (TH) onto a pre-treated glassy carbon electrode. This unique structure significantly enhances the electro-oxidation of dopamine (DA) and the reduction of hydrogen peroxide (HO), offering a sensitive detection method for both analytes. The electrode exhibits exceptional sensitivity, selectivity, and stability, demonstrating potential for practical applications in biosensing.

Emerging Trends in nanostructured materials-coated screen printed electrodes for the electrochemical detection of hazardous heavy metals in environmental matrices.

Heavy metal ions (HMIs) have become a significant contaminant in recent years. The increase in heavy metal pollution is a serious situation, requiring progressively robust, fast sensing, highly sensitive, and suitable techniques for heavy metal detection. Compared to other classical analytical methods, electroanalytical techniques, especially stripping voltammetric techniques with modified screen-printed electrodes (SPEs), have several advantages, such as fast sensing, great sensitivity, specificity, and long-time stability.

Fabrication of S and O-incorporated graphitic carbon nitride linked poly(1,3,4-thiadiazole-2,5-dithiol) film for selective sensing of Hg ions in water, fish, and crab samples.

Screen-printed carbon electrodes (SPCE) were modified with sulfur and oxygen-incorporated graphitic carbon nitride (S, O-GCN) linked poly(1,3,4-thiadiazole-2,5-dithiol) film (PTD) through thioester linkage. The promising interaction between the Hg and modified materials containing sulfur as well as oxygen through strong affinity was studied. This study was utilized for the electrochemical selective sensing of Hg ions by differential pulse anodic stripping voltammetry (DPASV).

Machine Learning-Enabled NIR Spectroscopy. Part 2: Workflow for Selecting a Subset of Samples from Publicly Accessible Data.

An increasingly large dataset of pharmaceutics disciplines is frequently challenging to comprehend. Since machine learning needs high-quality data sets, the open-source dataset can be a place to start. This work presents a systematic method to choose representative subsamples from the existing research, along with an extensive set of quality measures and a visualization strategy.

A Tribute to Professor Saranjit Singh - A Critical Thinker, Innovator, Mentor, and Educator.

This commentary presents contributions and accomplishments of Professor Saranjit Singh, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India, to pharmaceutical research and education. Prof. Singh completed his successful tenure in October 2021.

Enhanced biological nitrate removal by gCN/TiO composite and role of extracellular polymeric substances.

The biological denitrification in the presence of gCN doped TiO composite was investigated through series of batch experiment. gCN doped TiO was synthesized and characterized by FT-IR, XRD, SEM-EDAX and the prepared composite used as electron donor for the enhancement biological denitrification. The role of extracellular polymeric substances in the biological nitrate reduction and electron transfer process has been elucidated.

Electrochemical determination of 4-nitrophenol in environmental water samples using porous graphitic carbon nitride-coated screen-printed electrode.

We demonstrate a facile preparation of novel oxidized graphitic carbon nitride (O-gCN) applied as an efficient electrocatalyst for highly sensitive electrochemical detection of 4-nitrophenol (4-NP) in environmental water samples. As-prepared O-gCN were characterized by attenuated total reflection infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction methods for the confirmation of different functional groups and structural phase of O-gCN. The surface morphology of the O-gCN was characterized using field emission scanning electron microscopy and high-resolution transmission electron microscopy.

A nanocomposite consisting of porous graphitic carbon nitride nanosheets and oxidized multiwalled carbon nanotubes for simultaneous stripping voltammetric determination of cadmium(II), mercury(II), lead(II) and zinc(II).

A 3D nanocomposite consisting of porous graphitic carbon nitride nanosheets (p-g-CN-NSs) and oxidized multiwalled carbon nanotubes (O-MWCNTs) was prepared by simultaneous chemical oxidation of bulk g-CN and bulk MWCNTs. This one-step oxidation results in the formation of acidic functional groups on the basal surfaces of both g-CN and MWCNTs. Simultaneously, the O-MWCNTs are incorporated in-situ on the porous structure of p-g-CN.