Integrative miRNA-mRNA functional analysis identifies miR-182 as a potential prognostic biomarker in breast cancer.

Breast cancer (BC) is a heterogeneous disease distinct from major clinical hindrances, and microRNAs (miRNAs) have been accounted to partake in BC progression. Identifying potential miRNAs and their pathological significance in BC could pave the way for precisely targeted treatments. This study exploits transcriptomic BC miRNA, mRNA cohorts, and prognostic significance via an integrative functional approach.

Systemic Multi-Omics Analysis Reveals Amplified P4HA1 Gene Associated With Prognostic and Hypoxic Regulation in Breast Cancer.

Breast cancer (BC) is a common malignant tumor in females around the world. While multimodality therapies exist, the mortality rate remains high. The hypoxic condition was one of the potent determinants in BC progression.

Osteomyelitis of Maxilla: A Rare Finding from a Radiologist Point of View.

Osteomyelitis is an inflammatory process of both cortical and medullary bone. In the maxillofacial skeleton, it can be seen more commonly in mandible as compared to the maxilla. Here, we present a rare case of osteomyelitis involving the entire maxillae in a 55-year-old male patient highlighting the clinical findings and radiographic features with treatment modalities.

Hypoxia stimulates microenvironment in human embryonic stem cell through inflammatory signalling: An integrative analysis.

Despite, several lines of evidence suggesting the possible role of hypoxia in stem cell development and differentiation its significance in conferring the stemness and pluripotency remains elusive. In the present study we sought to delineate the candidate genes and molecular pathways imposed during hypoxic microenvironment and its physiological relevance in tipping the balance between the niche and cellular differentiation. Integrated meta-analysis was performed between the hypoxia exposed and normal human embryonic stem cells, employing three transcriptomic cohorts (GSE35819, GSE9510 and GSE37761) retrieved from Gene expression omnibus (GEO) database.

In silico analysis of expression pattern of a Wnt/β-catenin responsive gene ANLN in gastric cancer.

Actin-binding protein anillin (ANLN) is primarily involved in the cytokinesis and known to be dysregulated in many cancers including gastric cancer (GC). However, the regulation and clinical significance of ANLN in GC are far less clear. In the present study, we aimed to investigate the clinical significance and possible regulators of ANLN in GC.