Whole genome sequence of seaweed endophyte Bacillus halotolerans strain AUPP for antagonistic activity against Fusarium incarnatum causing chilli fruit rot.

Endophytes isolated from seaweeds emerge as promising biocontrol agents against broad spectrum of plant diseases. The endophytic bacteria were isolated from the seaweed (Sargassum wightii) to manage the chilli fruit rot pathogen Fusarium incarnatum. The antifungal activity of the isolated bacteria was tested by dual culture assay and plant growth-promoting activity was also tested by the standard paper towel method.

Effects of piperine-haloperidol mixture on ketamine induced schizophrenia rats and metabolism-mediated inhibitory potency: in-vivo and in-vitro evaluation.

Haloperidol, a conventional antipsychotic, was mixed with piperine in a ketamine-induced schizophrenia rat model to evaluate the interaction potential of this mixture through in-vitro and in-vivo analyses. Piperine, known for its CYP450 enzyme inhibitory effects, enhances the bioavailability of various drugs. Initial in-vitro assays using a high-throughput fluorometric method showed that the haloperidol-piperine mixture inhibited CYP3A4 and CYP2D6 enzymes, comparable to positive controls.

Bioassay-Guided Isolation of Guggulsterol I and Evaluation of Its Antioxidant Properties in Ethanol Extracts From Commiphora caudata Leaves.

The secondary metabolites of various parts of have shown a range of biological activities under both in vivo and in vitro conditions, particularly anti-inflammatory and antioxidant properties. While E-guggulsterone from this plant has been proven to have anti-inflammatory effects, the antioxidant potential of phytochemicals present in the leaves of is less explored. This investigation aimed to isolate an antioxidant phytoconstituent from the ethanolic extract of the dried leaves of using a bioassay-guided approach.

Combined effects of vitamin D3 and dioxopiperidinamide derivative on lipid homeostasis, inflammatory pathways, and redox imbalance in non-alcoholic fatty liver disease in vivo zebrafish model.

Liver damage and metabolic dysfunctions, the defining features of non-alcoholic fatty liver disease (NAFLD), are marked by inflammation, oxidative stress, and excessive hepatic fat accumulation. The current therapeutic approaches for NAFLD are limited, necessitating exploring novel treatment strategies. Dioxopiperidinamide derivatives, particularly DOPA-33, have shown effective anti-inflammatory and antioxidant properties, potentially offering therapeutic benefits against NAFLD.

Indole-3-acetic acid exposure leads to cardiovascular inflammation and fibrosis in chronic kidney disease rat model.

Indole-3-acetic acid (IAA), a protein-bound uremic toxin, has been linked to cardiovascular morbidity and mortality in chronic kidney disease (CKD) patients. This study explores the influence of IAA (125 mg/kg) on cardiovascular changes in adenine sulfate-induced CKD rats. HPLC analysis revealed that IAA-exposed CKD rats had lower excretion and increased circulation of IAA compared to both CKD and IAA control groups.

Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model.

The prevalent use of Azorubine (E122) and the unintentional food additive, Bisphenol A (BPA), in ready-to-drink (RTD) beverages raises significant health concerns, especially for children. The combined impact on embryonic development must be explored despite individual safety assessments. Our investigation revealed that the combined exposure of E122 and BPA at beverage concentration significantly induces mortality and morphological deformities, including reduced growth, pericardial edema, and yolk sac edema.

Risk Factors of Early Childhood Caries among Preschool Children in Madipakkam, Chennai: Cross-Sectional Survey.

Background: Early childhood caries (ECC) is a major oral health problem, mainly in socially disadvantaged populations. ECC affects infants and preschool children worldwide.

Aim: A survey to identify the factors influencing the ECC among preschool children in Madipakkam, Chennai.

Detection of Marchiafava Bignami disease using distinct deep learning techniques in medical diagnostics.

Purpose: To detect the Marchiafava Bignami Disease (MBD) using a distinct deep learning technique.

Background: Advanced deep learning methods are becoming more crucial in contemporary medical diagnostics, particularly for detecting intricate and uncommon neurological illnesses such as MBD. This rare neurodegenerative disorder, sometimes associated with persistent alcoholism, is characterized by the loss of myelin or tissue death in the corpus callosum.

Daidzein ameliorates nonmotor symptoms of manganese-induced Parkinsonism in zebrafish model: Behavioural and biochemical approach.

Background And Purpose: Parkinson's disease (PD) is a prevalent neurodegenerative movement disorder characterized by motor dysfunction. Environmental factors, especially manganese (Mn), contribute significantly to PD. Existing therapies are focused on motor coordination, whereas nonmotor features such as neuropsychiatric symptoms are often neglected.

Liquid chromatography-tandem mass spectrometry determination of bumetanide in human plasma and application to a clinical pharmacokinetic study.

Determining a drug's bioavailability and bioequivalence is important for developing and approving a drug product. The procedure supports applications for generic drug products and novel therapeutic substances, makes important decisions regarding safety and efficacy, and measures a drug's concentration in biological matrices. This study aimed to develop and validate a specific, simple, sensitive, and accurate method using liquid chromatography-tandem mass spectrometry (LC-MS) for measuring bumetanide (BUM) in human plasma.

Characterization of field isolates of Fusarium spp. from eggplant in India for species complexity and virulence.

Eggplant wilt, despite emerging as a severe disease in India, the etiology must be better studied for its species' complexity and variability. The identity of fungal isolates associated with eggplants of India was established morphologically followed by sequencing and phylogenetic analysis. Three species, Fusarium falciforme, Fusarium incarnatum and Fusarium proliferatum, were observed for the first time in India.

Prenatal diagnosis of fetal bradyarrhythmia and postnatal outcome.

Introduction: Prenatal diagnosis of Fetal bradyarrhythmia leads to parental and care provider anxiety as data on outcome is scarce. We aimed to correlate the prenatal presentation of fetal bradyarrhythmia with postnatal outcome.

Methods: Retrospective analysis of case records from 2017 to 2021.

Mechanical, tribological, and surface morphological studies on the effects of hybrid ilmenite and silicon dioxide fillers on glass fibre reinforced epoxy composites.

Recently, researchers have been attempting to enhance the mechanical and tribological characteristics of thermosetting epoxy composites by incorporating inorganic nanoparticles and ensuring their uniform distribution throughout the matrix. This study characterises ball-milled ilmenite (FeTiO-size of 63 nm) and silicon dioxide (SiO-size of 67.5 nm) fillers added to epoxy in proportions of 0:0, 2.

Deformation of optical solitons in a variable-coefficient nonlinear Schrödinger equation with three distinct PT-symmetric potentials and modulated nonlinearities.

We investigate deformed/controllable characteristics of solitons in inhomogeneous parity-time (PT)-symmetric optical media. To explore this, we consider a variable-coefficient nonlinear Schrödinger equation involving modulated dispersion, nonlinearity, and tapering effect with PT-symmetric potential, which governs the dynamics of optical pulse/beam propagation in longitudinally inhomogeneous media. By incorporating three physically interesting and recently identified forms of PT-symmetric potentials, namely, rational, Jacobian periodic, and harmonic-Gaussian potentials, we construct explicit soliton solutions through similarity transformation.

Hepatoprotective effect of dihydroxy piperlongumine in high cholesterol-induced non-alcoholic fatty liver disease zebrafish via antioxidant activity.

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are a growing epidemic and the most common liver diseases. Consumption of a western diet with high fats alters redox status, induces inflammation, and impairs the physiological function of hepatocytes. However, the pharmacological market lacks anti-NAFLD/NASH drugs.

Physiological race characterisation of Fusarium oxysporum strains infecting tomato employing candidate pathogenicity genes and host resistance.

Physiological races of 14 strains of Fusarium oxysporum f.sp. lycopersici were established by PCR profiling SIX gene expressions.

In Situ/Operando Characterization Techniques: The Guiding Tool for the Development of Li-CO Battery.

In recent times, the Li-CO battery has gained significant importance arising from its higher gravimetric energy density (1876 Wh kg ) compared to the conventional Li-ion batteries. Also, its ability to utilize the greenhouse gas CO to operate an energy storage system and the prospective utilization on extraterrestrial planets such as Mars motivate to practicalize it. However, it suffers from numerous challenges such as (i) the reluctant CO reduction/evolution; (ii) solid/liquid/gas interface blockage arising from the deposition of Li CO discharge product on the cathode; (iii) high overpotential to decompose the stable discharge product Li CO ; and (iv) instability of the electrolytes.

comparison of cytochrome P450 inhibitory and dopaminergic activity of Piperine, Curcumin and Capsaicin.

Psychiatric disorders are a heterogeneous group of mental disorders that manifest as abnormal mental or behavioral habits that cause the individual discomfort or disability. Dopamine imbalance plays a major role in many psychiatric disorders. Piperine, Curcumin and Capsaicin are CYP P450 3A4 & 2D6 inhibitors.

Data driven soliton solution of the nonlinear Schrödinger equation with certain P T-symmetric potentials via deep learning.

We investigate the physics informed neural network method, a deep learning approach, to approximate soliton solution of the nonlinear Schrödinger equation with parity time symmetric potentials. We consider three different parity time symmetric potentials, namely, Gaussian, periodic, and Rosen-Morse potentials. We use the physics informed neural network to solve the considered nonlinear partial differential equation with the above three potentials.

Stimulus-Induced Narrowband Gamma Oscillations are Test-Retest Reliable in Human EEG.

Visual stimulus-induced gamma oscillations in electroencephalogram (EEG) recordings have been recently shown to be compromised in subjects with preclinical Alzheimer's Disease (AD), suggesting that gamma could be an inexpensive biomarker for AD diagnosis provided its characteristics remain consistent across multiple recordings. Previous magnetoencephalography studies in young subjects have reported consistent gamma power over recordings separated by a few weeks to months. Here, we assessed the consistency of stimulus-induced slow (20-35 Hz) and fast gamma (36-66 Hz) oscillations in subjects ( = 40) (age: 50-88 years) in EEG recordings separated by a year, and tested the consistency in the magnitude of gamma power, its temporal evolution and spectral profile.

Middle hepatic vein reconstruction in adult living donor liver transplantation: a randomized clinical trial.

Background: In adult right lobe living donor liver transplantation (LDLT), venous drainage of the anterior sector is usually reconstructed on the bench to form a neo-middle hepatic vein (MHV). Reconstruction of the MHV for drainage of the anterior sector is crucial for optimal graft function. The conduits used for reconstruction include cryopreserved allografts, synthetic grafts, or the recipient portal vein.

Cyclic di-AMP: Small molecule with big roles in bacteria.

Cyclic dinucleotides are second messengers that are present in all the three domains of life, bacteria, archaea, and eukaryotes. These dinucleotides have important physiological and pathophysiological roles in bacteria. Cyclic di-AMP (cdA) is one of the recently discovered cyclic dinucleotides present predominantly in gram-positive bacteria.

The Effect of Plasticizers on the Polypyrrole-Poly(vinyl alcohol)-Based Conducting Polymer Electrolyte and Its Application in Semi-Transparent Dye-Sensitized Solar Cells.

In this work, the quasi-solid-state polymer electrolyte containing poly(vinyl alcohol)-polypyrrole as a polymer host, potassium iodide (KI), iodine (I), and different plasticizers (EC, PC, GBL, and DBP) was successfully prepared via the solution casting technique. Fourier transform infrared spectroscopy (FTIR) was used to analyze the interaction between the polymer and the plasticizer. X-ray diffraction confirmed the reduction of crystallinity in the polymer electrolyte by plasticizer doping.