Publications by authors named "Manik Bansal"
Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult.
Invest Ophthalmol Vis Sci
November 2024
Article Synopsis
- The study investigates how intraocular pressure (IOP) affects the mechanical damage to retinal ganglion cell axons, focusing on the specifics of axonal stretch and compression rather than just tissue-level impacts.
- Using optical coherence tomography (OCT) scans and histological images, the researchers reconstructed the volume occupied by axons and measured strains at different IOP levels to understand the mechanical insults on these axons.
- The findings reveal that axons in different regions experience various types of mechanical strain, suggesting that understanding these specific insults may help in connecting IOP changes with glaucoma development, and more research with larger groups is needed.
The optic nerve head (ONH) region at the posterior pole of the eye is supported by a fibrous structure of collagen fiber bundles. Discerning how the fibrous structure determines the region biomechanics is crucial to understand normal physiology, and the roles of biomechanics on vision loss. The fiber bundles within the ONH structure exhibit complex three-dimensional (3D) organization and continuity across the various tissue components.
View Article and Find Full Text PDFSclera collagen fiber microstructure and mechanical behavior are central to eye physiology and pathology. They are also complex, and are therefore often studied using modeling. Most models of sclera, however, have been built within a conventional continuum framework.
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