Silymarin attenuates benzo(a)pyrene induced toxicity by mitigating ROS production, DNA damage and calcium mediated apoptosis in peripheral blood mononuclear cells (PBMC).

Benzo(a)pyrene (B(a)P), which is the most studied member of PAH family is released into the environment (air, water and soil) from natural and man-made sources including industrial and automobile exhaust fumes. Since B(a)P is an omnipresent environmental pollutant and is believed to be a risk factor for human chemical carcinogenesis, it is important to identify potent naturally occurring/synthetic agents that could modulate B(a)P-induced toxicity. The present study explores the effect of the flavonoid silymarin (2.