Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP) Reduces Oral Malodor: A Randomized Clinical Study.

Background: Oral malodor, whether from systemic disease, dietary sources, or bacteria in the oral cavity, can negatively impact patients' quality of life. Oral malodor due to bacteria in the oral cavity can be managed by mechanically or chemically removing bacteria. Dentifrices are ideal vehicles to deliver therapeutic active ingredients that promote and maintain oral health since most consumers brush their teeth daily.

The Science of Developing Appealing Flavors to Drive Compliance.

Objectives: To develop flavors for oral care formulations containing zinc oxide, zinc citrate and L-arginine that are stable for the toothpaste shelf life, mask the unpleasant astringency and metallic off notes of the base, have an appealing taste which pleases global consumers, stimulate regimen compliance, and therefore help deliver whole mouth health benefits to people throughout the world.

Methods: For stability evaluation, flavor materials were formulated in Dual Zinc plus Arginine base and these samples were subjected to accelerated aging which consists of exposure to a temperature of 49°C for 6 weeks. The samples were analyzed by gas chromatography with flame ionization detector (GC FID) and gas chromatography mass spectrometry (GC MS) to confirm stability or establish changes in the chemical profile - loss of material and generation of degradation compounds.