First-in-Human Dose-Escalation Study of Fianlimab, an Antilymphocyte Activation Gene-3 Antibody, with Cemiplimab in Patients with Advanced Malignancies.

Purpose: Preclinical data indicate that fianlimab (antilymphocyte activation gene-3) plus cemiplimab (anti-PD-1) enhances antitumor activity. Here, we report prespecified final analyses of the dose-escalation part of a first-in-human, phase 1 study (NCT03005782) of fianlimab as monotherapy and in combination with cemiplimab in patients with advanced malignancies.

Patients And Methods: Adult patients received 1 to 40 mg/kg of fianlimab plus 350 mg of cemiplimab every 3 weeks (Q3W) across various dose-escalation schedules.

Phase I Study of Fianlimab, a Human Lymphocyte Activation Gene-3 (LAG-3) Monoclonal Antibody, in Combination With Cemiplimab in Advanced Melanoma.

Purpose: Coblockade of lymphocyte activation gene-3 (LAG-3) and PD-1 receptors could provide significant clinical benefit for patients with advanced melanoma. Fianlimab and cemiplimab are high-affinity, human, hinge-stabilized IgG4 monoclonal antibodies, targeting LAG-3 and PD-1, respectively. We report results from a first-in-human phase-I study of fianlimab and cemiplimab safety and efficacy in various malignancies including advanced melanoma.

Comprehensive review on lignocellulosic biomass derived biochar production, characterization, utilization and applications.

Biochar is an ample source of organic carbon prepared by the thermal breakdown of biomass. Lignocellulosic biomass is a promising precursor for biochar production, and has several applications in various industries. In addition, biochar can be applied for environmental revitalization by reducing the negative impacts through intrinsic mechanisms.

Label-free genosensing of dengue serotypes with an electrodeposited reduced graphene oxide-tris(bipyridine)ruthenium(II).

Constructing a label-free electrochemical transducer platform without compromising inherent biocompatibility against specific bioreceptor remains challenging, particularly probing nucleic acid hybridization at electrode interface without external redox-mediator. Here, we show that electrochemically reduced graphene oxide-tris(bipyridine)ruthenium(II) (ErGO-TBR) nanosheets electrodeposited on carbon screen printed electrode can quantify hybridization of clinically important target sequences specific to serotypes of dengue virus (DENV) non-structural 1 (NS1) protein. Different variables including deposition potential, time, and electrolytic composition were optimized for fabrication of label-free transducer platform.

Essential characteristics improvement of metallic nanoparticles loaded carbohydrate polymeric films - A review.

Petroleum-based films have contributed immensely to various environmental issues. Developing green-based films from carbohydrate polymers is crucial for addressing the harms encountered. However, some limitations exist on their property, processibility, and applicability that prohibit their processing for further developments.

Bioethanol production from agricultural residues as lignocellulosic biomass feedstock's waste valorization approach: A comprehensive review.

Bioenergy is becoming very popular, drawing attention as a renewable energy source that may assist in managing growing energy costs, besides possibly affording revenue to underprivileged farmers and rural populations worldwide. Bioethanol made from agricultural residual-biomass provides irreplaceable environmental, socioeconomic, and strategic benefits and can be considered as a safe and cleaner liquid fuel alternative to traditional fossil fuels. There is a significant advancement made at the bench scale towards fuel ethanol production from agricultural lignocellulosic materials (ALCM).

Green synthesis, characterization, and application of metal oxide nanoparticles for mercury removal from aqueous solution.

In this work, a novel surface-modified, green-based wheat straw-supported magnetite nanoparticles (FeO-NPs) were synthesized via the green synthesis method, and the adsorption of mercury (Hg(II)) ion from aqueous solutions was methodically investigated. The synthesized wheat straw-supported magnetite (FeO-WSS) NPs were characterized using X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and scanning electron microscopic (SEM) methods. FT-IR and TGA confirmed that the surface of FeO-NPs was functionalized well.

Current and prognostic overview on the strategic exploitation of anaerobic digestion and digestate: A review.

The depletion of fossil fuels and increasing demand for energy are encountered by generating renewable biogas. Anaerobic digestion (AD) produces not only biogas, also other value-added products from the digestate using various organic, municipal and industrial wastes which have several benefits like remediating waste, reduces greenhouse gas emissions, renewable energy generation and securing socio-economic status of bio-based industries. This review work critically analyzes the biorefinery approaches on AD process for the production of biogas and digestate, and their direct and indirect utilization.

Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial.

Background: Surgical resection of early stage hepatocellular carcinoma is standard clinical practice; however, most tumours recur despite surgery, and no perioperative intervention has shown a survival benefit. Neoadjuvant immunotherapy has induced pathological responses in multiple tumour types and might decrease the risk of postoperative recurrence in hepatocellular carcinoma. We aimed to evaluate the clinical activity of neoadjuvant cemiplimab (an anti-PD-1) in patients with resectable hepatocellular carcinoma.

Detoxification of coir pith through refined vermicomposting engaging Eudrilus eugeniae.

Hazardous coir industrial waste, coir pith has been subjected to 50 days vermicomposting with Eudrilus eugeniae by amending nitrogenous legume plant, Gliricidia sepium together with cattle dung in different combinations, after 21 days precomposting using Pleurotus sajor-caju spawn. An increase in electrical conductivity, total NPK and calcium, and a decrease in organic matter, total organic carbon, C/N ratio, C/P ratio and total phenolic content in the final vermicompost were observed. Dehydrogenase, urease and cellulase activity peaked up to 30 days of vermicomposting and then declined.

Waste Ox bone based heterogeneous catalyst synthesis, characterization, utilization and reaction kinetics of biodiesel generation from Jatropha curcas oil.

The present investigation has been carried out to utilize waste animal (Ox) bone for the progress of an innovative, low-budget, pollution free, and extremely resourceful heterogeneous catalyst synthesis for Jatropha curcas oil (JCO) conversion into biodiesel. The heterogeneous catalyst synthesized was characterized by its basic strength and subjected to spectroscopic (Fourier TransformInfrared and X-Ray Diffraction) and thermogravimetric analyses. Also, the physical properties of produced biodiesel were studied.

Heterogeneous base catalysts: Synthesis and application for biodiesel production - A review.

Recently, much research has been carried out to find a suitable catalyst for the transesterification process during biodiesel production where heterogeneous catalysts play a crucial role. As homogenous catalysts present drawbacks such as slow reaction rate, high-cost due to the use of food grade oils, problems associated with separation process, and environmental pollution, heterogenous catalysts are more preferred. Animal shells and bones are the biowastes suitably calcined for the synthesis of heterogenous base catalyst.

Precomposting and green manure amendment for effective vermitransformation of hazardous coir industrial waste into enriched vermicompost.

Vermitransformation of coir pith (CP) into enriched vermifertilizer has been achieved by amending a green-manure plant, Sesbania sesban (SS) for the first time, and cow dung (CD) in five different combinations: T1, T2, T3, T4 and T5. The substrates were 28 days precomposted with Pleurotus sajor-caju followed by 50 days vermicomposting with Eisenia fetida and Eudrilus eugeniae. Results showed a significant reduction in cellulose, lignin, organic carbon, C/N ratio, C/P ratio and an increase in plant nutrients compared to control.

Comparative analysis for the production of fatty acid alkyl esterase using whole cell biocatalyst and purified enzyme from Rhizopus oryzae on waste cooking oil (sunflower oil).

The petroleum fuel is nearing the line of extinction. Recent research and technology have provided promising outcomes to rely on biodiesel as the alternative and conventional source of fuel. The use of renewable source - vegetable oil constitutes the main stream of research.