A series of novel nimbolide derivatives bearing various substitutions on 28th position was designed and synthesized using Sonogashira (2a-2p) and Glaser coupling (3a-3e) reactions. The synthesized derivatives were assessed for in vitro cytotoxic activity against four different human cancer cell lines (A549 cells, MCF-7 cells, MDA-MB-231 cells, and HCT15 cells) and normal cell line (HEK cells) using MTT assay. Among the screened derivatives, the compound 3a showed potent activity against A549 cells with IC value of 0.
View Article and Find Full Text PDFBackground And Objectives: One of the potential negative effects of a lockdown are changes in dietary and lifestyle patterns, which can lead to weight gain. Our objective was to assess the changes on dietary habits and eating patterns in a lockdown situation and their impact on weight. We aimed to determine whether the treatment with GLP1 analogues (aGLP1) could impact on these parameters.
View Article and Find Full Text PDFBackground: From 2006 to 2011, biological activity of insecticides for Indoor Residual Spraying (IRS), conventional treatment of nets (CTNs) or long lasting insecticidal nets (LLINs) was evaluated before their approval in Cameroon. The objective of the study was to select the best tools for universal malaria vector control coverage.
Methodology: Bioassays were performed using WHO cones and the Kisumu susceptible strain of Anopheles gambiae s.
Background: Determination of residual activity of insecticides is essential information for the selection of appropriate indoor spraying operation. The present study was undertaken to evaluate the residual effect of three candidate insecticide formulations on different indoor surfaces in order to guide future interventions, in the context of Cameroon and other African countries.
Methods: The study was conducted in the Ntougou neighbourhood in Yaoundé (capital city of Cameroon).
A cholera epidemic was recorded in Douala, Cameroon in 1971. Another 8-month outbreak occurred in January 2004 and spread in rapid succession to all health districts in Douala. The purpose of this study was to assess the association between meteorology and cholera incidence and preventive action in the health districts.
View Article and Find Full Text PDFWell disinfection is generally recommended as an emergency response measure during cholera outbreaks. However few studies have been carried out to document chlorination techniques, prove the efficacy of chlorination, or determine how often disinfection should be performed. The purpose of this study was to test a handmade device for continuous chlorination, to measure the initial concentration of free residual chlorine, and monitor chlorine concentration to determine when renewal is necessary.
View Article and Find Full Text PDFCholera has been endemic in Douala, Cameroon since 1971. A number of environmental factors favourize the survival of the Vibrio in Douala including location at the mouth of Wouri delta on the Atlantic Ocean, sandy clay soil, shallow dirty polluted foul-smelling groundwater, presence of vast expanses of swamp, streams/drainage ditches infested with algae, and high temperatures with low rainfall and drought during certain periods of the year. Most outbreaks have started in Bepanda, a slum area built on a garbage dump in a swampy zone fed by drainage ditches carrying the faecal pollution from neighbouring upstream districts.
View Article and Find Full Text PDF