Publications by authors named "Manfred S Green"
Objectives: This study aimed to investigate the impact of a designated pharmacist (DPha) intervention in a hemato-oncology unit, focusing on reducing drug treatment costs and improving technical efficiency (TE).
Methods: Data from an 8-month intervention in the Israeli Clalit Health Services hemato-oncology outpatient unit were analyzed. During the study, the DPha reviewed the drug therapies being administered.
Background: Possible sex differences in hepatitis A virus (HAV) incidence rates in different age groups are not well documented. We aimed to obtain stable pooled estimates of such differences based on data from a number of high-income countries.
Methods: We obtained data on incident cases of HAV by sex and age group over a period of 6-25 years from nine countries: Australia, Canada, Czech Republic, Finland, Germany, Israel, Netherland, New Zealand and Spain.
Article Synopsis
- Non-polio enterovirus aseptic meningitis (NPE-AM) is an illness in infants that can look like serious bacterial infections (SBI) but generally resolves on its own.
- A study analyzed 1,278 hospitalized febrile infants under 3 months old, finding that NPE-AM was present in 16.2% of cases, with notable differences in symptoms like fever severity and rash occurrence compared to SBI and non-bacterial infections (NBI).
- Infants with NPE-AM often received antibiotics due to their similar presentation to bacterial infections, highlighting the need for faster testing methods to differentiate between these conditions.
In the paper published recently in this journal, Kumar et al. explained why the key to improved COVID-19 vaccine uptake is to understand societal reactions leading to vaccine hesitancy. They conclude that communications strategies should be tailored to the different phases of vaccine hesitancy.
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- The DOI mentioned (10.3389/fpubh.2022.997025) refers to a specific academic article in the field of public health.
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Article Synopsis
- - The study examines gender differences in tuberculosis incidence rates across different age groups and countries, highlighting inconsistencies in data over time.
- - Using data from seven countries, researchers calculated male-to-female incidence rate ratios (IRRs) for various age categories and found that men had significantly higher rates in older age groups.
- - The findings revealed that while boys under one year old had higher rates, boys aged 1-9 showed no significant difference, and a slight excess was noted in females aged 10-14, emphasizing the need to consider gender as a biological factor in tuberculosis risk assessments.
Article Synopsis
- - The report compares hospitalized patients with COVID-19 (152 patients) and seasonal influenza (136 patients), noting distinct differences in disease severity and clinical symptoms.
- - Influenza patients exhibited more issues like dyspnea, hypoxemia, and elevated liver enzymes, while COVID-19 patients were typically overweight, lymphopenic, and showed significant radiological abnormalities.
- - Although influenza patients were generally more severely ill upon admission, both groups experienced comparable lengths of hospital stay, need for ventilatory support, and 30-day mortality rates.
Article Synopsis
- - The study examines gender differences in measles incidence rates across various countries and age groups over 11-27 years, revealing that males generally have higher rates of infection up to age 44.
- - Male to female incidence rate ratios (IRRs) were calculated and meta-analytic methods were used to combine data, showing that excess measles rates in young males remain consistent, while women aged 45-64 show higher incidence.
- - The findings suggest that biological and physiological factors contribute to the higher infection rates in younger males, while differential exposure may influence older age groups, highlighting the potential for improved understanding of infection mechanisms and vaccination strategies.
A Pooled Analysis of Sex Differences in Rotaviral Enteritis Incidence Rates in Three Countries Over Different Time Periods.
Womens Health Rep (New Rochelle)
February 2022
Article Synopsis
- Sex differences in the incidence rates of rotaviral enteritis were analyzed over a period of 7-22 years across three countries, revealing higher rates in males among younger age groups (0-14 years) and reversed rates in adult females (15 years and older).
- Pooled analyses showed male-to-female incidence rate ratios (IRRs) of 1.12, 1.07, and 1.13 for children aged 0-4, 5-9, and 10-14 years, while adult ratios were 0.66, 0.78, and 0.78 for those aged 15-44, 45-64, and 65+, respectively.
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Article Synopsis
- - Adverse events from COVID-19 mRNA vaccines range from mild (like local pain) to severe (such as anaphylaxis), with limited data on age-specific gender differences.
- - Analysis from four studies shows that females reported higher rates of adverse events following the Pfizer-BioNTech vaccine, particularly after the second dose, including symptoms like fever and muscle pain.
- - The findings suggest a significant need for gender-based assessments of vaccine adverse events, which could influence future vaccine dosing schedules.
Article Synopsis
- The study investigates sex differences in salmonellosis incidence rates across various ages and countries from 1994 to 2016, revealing that young males generally have higher rates of infection compared to females.
- Analysis shows that for adolescents and adults aged 15-44 and 45-64, females exhibit significantly higher incidence rates, indicating complex sex-related factors in infection spread.
- Findings suggest genetic, hormonal, and microbiota interactions may explain these differences, highlighting the need for targeted research on sex-specific determinants in infectious disease management and vaccine development.
Gaps between physician and patient perceptions may lead to misunderstandings and mismanage of treatment. There are sparse data about the differences in opinions toward medical cannabis (MC) between patients and health professionals. The aim of this study was to examine the attitudes toward MC, its perceived efficacy, side effects and risk of dependency, among patients, nurses and physicians.
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- About 5.1 million Israelis were fully vaccinated with the Pfizer-BioNTech Covid-19 vaccine by May 31, 2021, leading to concerns about myocarditis, prompting the Israeli Ministry of Health to monitor the situation closely.
- The study reviewed cases of myocarditis from December 2020 to May 2021, finding that 283 cases were related to the vaccine, with 95% of cases being mild, though one was fatal.
- The findings indicated a higher risk of myocarditis after the second vaccine dose, particularly among males aged 16 to 19, with a risk difference of 1.76 per 100,000 people, and a significantly elevated standardized incidence ratio of 5.34.
Pertussis containing vaccine is recommended for pregnant women to protect neonates prior to being fully immunized against the disease. The immune response during pregnancy may be impacted by changes in the hormonal status. The aim of this study was to evaluate the immune response to pertussis immunization in pregnancy and to assess the role of sex hormones.
View Article and Find Full Text PDFBackground: Social inequalities affect the COVID-19 burden and vaccine uptake. The aim of this study was to explore inequalities in the incidence and mortality rate of SARS-CoV-2 infection and vaccine uptake in various sociodemographic and population group strata in Israel.
Methods: We analysed nationwide publicly available, aggregated data on PCR-confirmed SARS-CoV-2 infections and COVID-19 deaths between March 2020 and February 2021, as well as the first three months of COVID-19 immunisation according to sociodemographics, including population group and residential socioeconomic status (SES).
Background: Early in the COVID-19 pandemic, it was noted that males seemed to have higher case-fatality rates than females. We examined the magnitude and consistency of the sex differences in age-specific case-fatality rates (CFRs) in seven countries.
Methods: Data on the cases and deaths from COVID-19, by sex and age group, were extracted from the national official agencies from Denmark, England, Israel, Italy, Spain, Canada and Mexico.
Background: Vaccines for COVID-19 are currently available for the public in Israel. The compliance with vaccination has differed between sectors in Israel and the uptake has been substantially lower in the Arab compared with the Jewish population.
Aim: To assess ethnic and socio-demographic factors in Israel associated with attitudes towards COVID-19 vaccines prior to their introduction.
The Israel National Sera Bank: Methods, Representativeness, and Challenges.
Int J Environ Res Public Health
February 2021
The Israel National Sera Bank (INSB) was established in 1997 in the Israel Center for Disease Control. The purpose of the INSB was to provide policymakers with data on the immunity status of the Israeli population against vaccine-preventable diseases, and on the extent and characteristics of exposure to emerging and re-emerging infectious diseases. The aim of this paper is to describe the methods, representativeness, and challenges in maintaining the INSB.
View Article and Find Full Text PDFBackground: Crude case-fatality rates (CFRs) for COVID-19 vary widely between countries. There are serious limitations in the CFRs when making comparisons. We examined how the age distribution of the cases is responsible for the COVID-19 CFR differences between countries.
View Article and Find Full Text PDFThe magnitude and consistency of the sex differences in meningococcal disease incidence rates (IR) have not been systematically examined in different age groups, countries and time periods. We obtained national data on meningococcal disease IR by sex, age group and time period, from 10 countries. We used meta-analytic methods to combine the male to female incidence rate ratios (IRRs) by country and year for each age group.
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