Publications by authors named "Manfred Lambertz"
Background: Patients suspected to have upper gastrointestinal (UGI) cancer can be referred directly for investigation; however, at times this may result to inappropriate referrals. This study explores the model of a "one-stop" clinic as an alternative to the direct referral system. The current study aims to assess the feasibility and outcomes of a one-stop UGI clinic and evaluate sensitivity and specificity of "on-the-day" diagnoses.
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- Elevated levels of zinc (Zn), copper (Cu), and iron (Fe) in brain tissue have been linked to neuronal death, but there's no direct evidence proving metals cause this damage.
- Research in mutant mice demonstrated that prior to neurodegeneration, Zn and Fe levels were lower in the cerebellum compared to normal, and then all three metal concentrations increased significantly during excitotoxic cell death.
- The increase in metal concentrations occurred after a delay alongside the loss of cerebellar Purkinje cells, suggesting that elevated metal levels are a result of metabolic stress rather than a direct cause of neuronal death.
Selected examples from experiments in humans and dogs with time series of reticular neurons, respiration, arterial blood pressure and cutaneous forehead blood content fluctuations were analysed using multiscaled time-frequency distribution, post-event-scan and pointwise transinformation. We found in both experiments a "0.15-Hz rhythm" exhibiting periods of spindle waves (increasing and decreasing amplitudes), phase synchronized with respiration at 1:2 and 1:1 integer number ratios.
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