Pseudomonas aeruginosa resistance phenotypes and phenotypic highlighting methods.

Pseudomonas aeruginosa genus bacteria are well known for their increased drug resistance (phenotypic ang genotypic resistance). The most important resistance mechanisms are: enzyme production, reduction of pore expression, reduction of the external membrane proteins expression, efflux systems, topoisomerase mutations. These mechanisms often accumulate and lead to multidrug ressitance strains emergence.

Angiogenesis in the pathogenesis of pterygium.

Pterygium represents an epithelial hyperplasia associated with fibro-vascular growth. It is an active process, associate with cellular proliferation, remodeling of the connective tissue, angiogenesis and inflammation. The aim of this study consists of emphasizing angiogenesis involvement in the pterygium pathogeny.

[Laser trabeculoplasty--a prospective study].

Purpose And Method: Prospective study on 22 glaucoma patients (31 eyes)--pseudoexfoliation glaucoma and POAG--who underwent nonselective laser trabeculoplasty during 2007. The follow-up time is intended to be 5 years, with a preliminary report at 2 years. Our study wants to evaluate the efficiency and safety of the laser procedure.

[Etiopathogenic aspects in development and evolution of pterigyum].

Pterygium is an epithelial hyperplasia accompanied by a fibrovascular growth originating at the corneo-conjunctival junction, from where the modified limbic cells migrate and surpass the cornea. The studies reviewed show that it is an active process associated with cell growth, remodelling of the connective tissue, angiogenesis and inflammation. Despite the lack of knowledge regarding the pathogenesis of pterygia, epidemiologic evidence suggests that exposure to UV-irradiation may be an initial trigger in the development of this lesion.

[Assessment of systane in severe dry eye].

The study proposes the evaluation of the Systane effect on people that have severe dry eye sensation, with cornea or conjunctive complications. In order to do this, a study protocol has been adopted which meant comparing the values of lacrimal film break-up time, before and after Systane treatment, comparing cornea and conjunctive staining, comparing the crystallization test before and after treatment, comparing the conjunctival impression before and after treatment, and the general acceptability of Systane. The study results have shown that in severe dry eye cases, Systane increases lacrimal film break-up time by 2-3 seconds than the initial value, as well as considerable reduction in cornea/conjunctival staining and in conjunctival hyperemia in Sicca keratoconjunctivitis.

[Corneal neurotrophic ulcers--clinical and etiopathogenic aspects].

Purpose: The aim of this paper is to observe the corneal neurotrophic ulcers in patients with ophthalmic and systemic diseases associated with impairment of the sensory innervation of the cornea.

Methods: We have performed a retrospective study using a lot of patients with corneal neurotrophic ulcers, admitted in Ophthalmology Clinic in 2003-2006. We have analyzed the etiopathogenic factors that have determined the corneal trophic ulcers, the treatment and the complications occurred.

[Ophthalmic manifestation in icterus--hemorrhagic leptospirosis].

We present the case of a 19-year-old male, admitted in the Ophthalmology Clinic for Macular Chorioretinitis, hemorrhagic form. Laboratory findings shown high titres of icterus-hemorrhages leptospirosis.

[Takayasu disease--case report].

Chronic vasculitis which determines the thickness of the affected arteries, Takayasu disease is an uncommon finding. It is characterized by narrowing of the big arteries beginning from the aortic arch. The result is arterial hypotension, cerebral and retinal ischemic signs, the absence of pulse at the upper limbs.

[Anterior uveitis in a juvenile chronic arthritis, oligoarticular form].

We present the case of a 16-year-old male teen-ager admitted in the Ophthalmology Clinic Craiova, diagnosed with Anterior neglected acute uveitis in the left eye. Before and simultaneous with the ocular manifestations, the patient complained of pain on the hips joints. The pediatric examination, based on the clinical features and the laboratory findings, diagnosed him with Juvenile chronic arthritis, oligoarthritis type.

[Doyne retinal dystrophy--case report].

We present the case of a female patient, 16-years old, whose the fundus examination revealed the presence, in the macular region, of drusen type lesions; the clinical aspect completed with AFG, perimetry, dark adaptation, ERG resulted in the diagnosis of Doyne's honeycomb retinal dystrophy. The disorder, included in the Familial drusen, is due to an inborn error of metabolism localized the RPE. It seems that the defect is in an intercellular matrix protein which leads to the development of abnormal basement membranes.

[Retinal vascular lesions in diabetic retinopathy].

The paper presents the vascular morphopathological lesions in diabetic retinopathy. We have initiated a comparative study between normal eye and ocular globes preserved from patients with diabetic retinopathy in different stages of evolution that were fixed and stained by classic histological techniques. We have focus on the histopathological examinations on arterial and venous morphology, in different retinal areas (central and peripheral).

[Changes of the conjunctival nervous fillets in diabetic patients].

Purpose: Our study suggested to reveal nervous fillets changes from conjunctiva structure in patients with diabetes.

Material And Method: We removed bulbar conjunctiva during cataract surgery on diabetic and non-diabetic patients from the same age group. The conjunctiva fragments were fixed in Lillie's solution, then studied by using optical microscopy with usual and histochemical stainings.

[Neuroprotective effect of Betoptic S-considerations after 18 months of treatment].

Background: The aim of our study was the analysis of the hypotensor and neuroprotector effect induced by Betoptic S given to patients diagnosed with open-angled glaucoma.

Materials And Methods: A set of patients with open-angled glaucoma at different stages of evolution, during a period of 18 months were available for our examination. We took in to account parametres such as: ocular pressure values, fundus examination, kinetic and automatic perimetry.