An Inverse FEM for Structural Health Monitoring of a Containership: Sensor Network Optimization for Accurate Displacement, Strain, and Internal Force Reconstruction.

In naval engineering, particular attention has been given to containerships, as these structures are constantly exposed to potential damage during service hours and since they are essential for large-scale transportation. To assess the structural integrity of these ships and to ensure the safety of the crew and the cargo being transported, it is essential to adopt structural health monitoring (SHM) strategies that enable real-time evaluations of a ship's status. To achieve this, this paper introduces an advancement in the field of smart sensing and SHM that improves ship monitoring and diagnostic capabilities.

Embracing the challenges of neonatal and paediatric pulmonary hypertension.

Paediatric pulmonary arterial hypertension (PAH) shares common features with adult disease, but is associated with several additional disorders and challenges that require unique approaches. This article discusses recent advances, ongoing challenges and distinct approaches for caring for infants and children with PAH, as presented by the paediatric task force of the 7th World Symposium on Pulmonary Hypertension. We provide updates on diagnosing, classifying, risk-stratifying and treating paediatric pulmonary hypertension (PH) and identify critical knowledge gaps.

Calibration and validation of solar radiation-based equations to estimate crop evapotranspiration in a semi-arid climate.

The Abtew and Jensen-Haise solar radiation-based equations were used to estimate evapotranspiration, considering the limited climatic data in many locations. Both equations were proven to successfully predict the potential evapotranspiration (ET) compared with the standard Penman-Monteith (PM) method in two Mediterranean countries. Calibration of the constant coefficient k of the Abtew equation showed substantial differences compared to recommended values (1.

Numerical Study on the Damage of a Carbon Woven Composite Panel Subjected to Blast Loading.

Blast loading represents a critical dynamic condition for engineering structures. While the response of metal materials to such a condition has been studied in detail, the behavior of composites has not been properly addressed yet. In this context, this work leverages numerical methods to assess the damage that occurs in a carbon-fiber-reinforced polymer plate subjected to close-range blast loading.

Pharmacomicrobiomics of Classical Immunosuppressant Drugs: A Systematic Review.

The clinical response to classical immunosuppressant drugs (cIMDs) is highly variable among individuals. We performed a systematic review of published evidence supporting the hypothesis that gut microorganisms may contribute to this variability by affecting cIMD pharmacokinetics, efficacy or tolerability. The evidence that these drugs affect the composition of intestinal microbiota was also reviewed.

Identification of Drugs Acting as Perpetrators in Common Drug Interactions in a Cohort of Geriatric Patients from Southern Italy and Analysis of the Gene Polymorphisms That Affect Their Interacting Potential.

Background: Pharmacogenomic factors affect the susceptibility to drug-drug interactions (DDI). We identified drug interaction perpetrators among the drugs prescribed to a cohort of 290 older adults and analysed the prevalence of gene polymorphisms that can increase their interacting potential. We also pinpointed clinical decision support systems (CDSSs) that incorporate pharmacogenomic factors in DDI risk evaluation.

Comparison of different treatment strategies in patients with chronic thromboembolic pulmonary hypertension: a single centre real-world experience.

Background: Pulmonary endarterectomy (PEA) has been the most effective therapy for chronic thromboembolic pulmonary hypertension (CTEPH). However, there is a substantial proportion of patients deemed not operable in whom other treatment strategies are available: medical therapy and balloon pulmonary angioplasty (BPA). We aimed to compare different CTEPH treatment strategies effect in a real-world setting.

Pulmonary Arterial Hypertension Associated with Portal Hypertension and HIV Infection: Comparative Characteristics and Prognostic Predictors.

Background: Pulmonary arterial hypertension (PAH) may complicate both portal hypertension (Po-PAH) and HIV infection (HIV-PAH). These two conditions, however, frequently coexist in the same patient (HIV/Po-PAH). We evaluated clinical, functional, hemodynamic characteristics and prognostic parameters of these three groups of patients.

Progress in the treatment of acute pulmonary embolism and chronic thrombo-embolic pulmonary hypertension/disease.

The combination of an initial clinical approach aimed at evaluating the early risk of mortality with subsequent diagnostic and therapeutic approaches articulated on the overall patient's profile is recommended in acute pulmonary embolism (PE). The presence of pulmonary hypertension associated with the persistence of chronic vascular obstructions in the pulmonary arteries after one or more acute thrombo-embolic events identifies a condition defined as chronic thrombo-embolic pulmonary hypertension (CTEPH). The evolution of technology and knowledge in the field of imaging has allowed us to qualify the computed tomography angiography of the pulmonary arteries as the gold standard for the diagnostic confirmation of both acute PE and CTEPH.

Experimental and Numerical Study of the Influence of Pre-Existing Impact Damage on the Low-Velocity Impact Response of CFRP Panels.

This paper presents an experimental and numerical investigation on the influence of pre-existing impact damage on the low-velocity impact response of Carbon Fiber Reinforced Polymer (CFRP). A continuum damage mechanics-based material model was developed by defining a user-defined material model in Abaqus/Explicit. The model employed the action plane strength of Puck for the damage initiation criterion together with a strain-based progressive damage model.

Castor Oil-Based Polyurethane/S2 Glass/Aramid Hybrid Composites Manufactured by Vacuum Infusion.

This study evaluates the hybridization effect of S2-glass/aramid on polyurethane (PU) composites produced by vacuum infusion. Different laminates were produced with similar thickness (around 2.5 mm), using, as reinforcement, only aramid fabrics (five layers, named as K) or only S2-glass fabrics (eight layers, named as G).

A Numerical Study on the Influence of Strain Rate in Finite-Discrete Element Simulation of the Perforation Behaviour of Woven Composites.

Predicting the perforation limit of composite laminates is an important design aspect and is a complex task due to the multi-mode failure mechanism and complex material constitutive behaviour required. This requires high-fidelity numerical models for a better understanding of the physics of the perforation event. This work presents a numerical study on the perforation behaviour of a satin-weave S2-glass/epoxy composite subjected to low-velocity impact.

Therapeutic alternatives in chronic thromboembolic pulmonary hypertension: from pulmonary endarterectomy to balloon pulmonary angioplasty to medical therapy. State of the art from a multidisciplinary team.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease with a very complex pathophysiology differing from other causes of pulmonary hypertension (PH). It is an infrequent consequence of acute pulmonary embolism that is frequently misdiagnosed. Pathogenesis has been related to coagulation abnormalities, infection or inflammation, although these disturbances can be absent in many cases.

A pragmatic approach to risk assessment in pulmonary arterial hypertension using the 2015 European Society of Cardiology/European Respiratory Society guidelines.

Objective: To optimise treatment of patients with pulmonary arterial hypertension (PAH), the 2015 European Society of Cardiology/European Respiratory Society guidelines recommend using risk stratification, with the aim of patients achieving low-risk status. Previous analyses of registries made progress in using risk stratification approaches, however, the focus is often on patients with a low-risk prognosis, whereas most PAH patients are in intermediate-risk or high-risk categories. Using only six parameters with high prognostic relevance, we aimed to demonstrate a pragmatic approach to individual patient risk assessment to discriminate between patients at low risk, intermediate risk and high risk of death.

[Progress in the treatment of pulmonary vascular diseases].

Multiple progresses have been achieved in pulmonary vascular diseases in the last decades, including the areas of pulmonary hypertension and pulmonary thromboembolic disease. The increase in knowledge has been accomplished in pathophysiological, clinical and treatment domains and has included as examples the discovery of gene mutations related to the hereditary forms of pulmonary arterial hypertension and the proposals of personalized treatment algorithms in patients with acute pulmonary embolism, chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension, validated in this specific area by more than 45 randomized controlled trials. The diagnostic processes have been refined, increasing the awareness that appropriate and precise diagnosis is essential for the optimal treatment strategy.

[Balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension:a paradigmatic case report].

Chronic thromboembolic pulmonary hypertension (CTEPH) is a complex disease where organized pulmonary thrombi and progressive vascular remodeling of the pulmonary arterial tree act synergistically to increase pulmonary vascular resistance and cause pulmonary hypertension. Balloon pulmonary angioplasty (BPA) has gained a renewed interest for the treatment of patients with CTEPH who are not undergoing surgery with pulmonary endarterectomy (PEA) or with persistent/recurrent pulmonary hypertension after PEA and has shown promising results in several observational studies conducted to date. We describe the case of a 42-year-old man with inoperable CTEPH in NYHA functional class III who normalized functional capacity, hemodynamic profile and main hemodynamic parameters after three BPA sessions.

[Balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: 5 years of experience in Italy].

Background: Balloon pulmonary angioplasty (BPA) represents a therapeutic option for the treatment of chronic thromboembolic pulmonary hypertension (CTEPH) in patients who are not eligible for surgical pulmonary endarterectomy (PEA) or with persistent/recurrent symptomatic pulmonary arterial hypertension after PEA. This study evaluated the safety of BPA during 5 years of experience of the only Italian center systematically performing this procedure.

Methods: The BPA program was activated at the S.

Experimental and Numerical Investigation on the Perforation Resistance of Double-Layered Metal Shield under High-Velocity Impact of Armor-Piercing Projectiles.

In the case of protection of transportation systems, the optimization of the shield is of practical interest to reduce the weight of such components and thus increase the payload or reduce the fuel consumption. As far as metal shields are concerned, some investigations based on numerical simulations showed that a multi-layered configuration made of layers of different metals could be a promising solution to reduce the weight of the shield. However, only a few experimental studies on this subject are available.