Publications by authors named "Manel Castells-Esteve"
Background: Kidney transplantation is associated with a high risk of infectious complications due to immunosuppressive therapy. Although infections may be transmitted from donor to transplant recipient through contaminated preservation solution (PS), the clinical impact of this is not well-understood.
Methods: We retrospectively evaluated PS contamination rates in a series of 339 patients who underwent cadaveric renal transplant at our centre.
Intraethnic variation in steroid-5-alpha-reductase polymorphismsin prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment.
J Genet
June 2015
Genetic variations in genes involved in testosterone metabolism are associated with prostate cancer progression: A Spanish multicenter study.
Urol Oncol
July 2015
Article Synopsis
- - The study investigates the impact of genetic variations in specific androgen metabolism genes (CYP17A1, SRD5A1, and SRD5A2) on prostate cancer risk and characteristics among Spanish patients.
- - Researchers analyzed 494 patients with nonmetastatic localized prostate cancer, focusing on 32 single nucleotide polymorphisms (SNPs) and found significant associations between certain SNPs in the SRD5A1 gene and higher prostate-specific antigen levels at diagnosis.
- - Results indicated that nonhomozygous patients for a specific haplotype demonstrated a significantly greater risk of larger tumor size and higher Gleason scores, suggesting that SNPs in SRD5A1 may influence the severity of
Background: Besides serum levels of PSA, there is a lack of prostate cancer specific biomarkers. It is need to develop new biological markers associated with the tumor behavior which would be valuable to better individualize treatment. The aim of this study was to elucidate the relationship between single nucleotide polymorphisms (SNPs) in genes involved in DNA repair and prostate cancer progression.
View Article and Find Full Text PDFPolymorphisms in DNA-repair genes in a cohort of prostate cancer patients from different areas in Spain: heterogeneity between populations as a confounding factor in association studies.
PLoS One
March 2014
Background: Differences in the distribution of genotypes between individuals of the same ethnicity are an important confounder factor commonly undervalued in typical association studies conducted in radiogenomics.
Objective: To evaluate the genotypic distribution of SNPs in a wide set of Spanish prostate cancer patients for determine the homogeneity of the population and to disclose potential bias.
Design Setting And Participants: A total of 601 prostate cancer patients from Andalusia, Basque Country, Canary and Catalonia were genotyped for 10 SNPs located in 6 different genes associated to DNA repair: XRCC1 (rs25487, rs25489, rs1799782), ERCC2 (rs13181), ERCC1 (rs11615), LIG4 (rs1805388, rs1805386), ATM (rs17503908, rs1800057) and P53 (rs1042522).