Publications by authors named "Manel Boussouf"
Article Synopsis
- The study investigates protein-rich inclusions in neurodegeneration, noting that current iPSC models lack reproducibility and speed in developing these inclusions.
- Researchers created new iPSC models that allow for rapid production of CNS cells with proteins prone to aggregation, enabling the tracking of inclusions at a single level.
- They identified various inclusion types with differing effects on neuron survival and isolated proteins that could influence toxicity, paving the way for improved drug development for neurodegenerative diseases.
NPJ Parkinsons Dis
October 2022
Article Synopsis
- Antibodies that target a specific part of a protein called phosphorylated alpha-synuclein (pS129) are important for studying diseases like Parkinson's.
- Researchers found that different changes to this protein can affect how well these antibodies work in detecting it in the brain and other tissues.
- The study also highlighted that not all antibodies are accurate and that better, more reliable antibodies need to be developed to improve research and diagnosis of these diseases.
