Publications by authors named "Manel Benhassine"

Uveal melanoma (UM) remains the most common intraocular malignancy among diseases affecting the adult eye. The primary tumor disseminates to the liver in half of patients and leads to a 6 to 12-month survival rate, making UM a particularly aggressive type of cancer. Genomic analyses have led to the development of gene-expression profiles that can efficiently predict metastatic progression.

View Article and Find Full Text PDF
Article Synopsis
  • Understanding corneal wound healing is crucial for developing tissue-engineered human corneas (hTECs) and reducing the need for donor corneas.
  • The study revealed that a specific gene's expression is significantly repressed during the healing of hTEC wounds, indicating this repression is essential for wound closure.
  • Additionally, the research identified critical transcription factors (AP-1 and Sp1/Sp3) involved in regulating gene activity, which also show reduced expression during the wound healing process.
View Article and Find Full Text PDF

Uveal melanoma (UM), although a very rare disease, remains a particularly aggressive type of cancer as near 50% of the UM presenting patients will also develop liver metastases within 15 years from the initial diagnostic. One of the most reliable predictive markers of UM at risk of evolving toward the formation of liver lesions is an abnormally elevated level of expression of the transcript encoding the 5-Hydroxytryptamine (serotonin) receptor 2B (HTR2B). In our previous study, we demonstrated that transcription of the HTR2B gene was under the regulatory influences of two transcription factors (TFs), NFI and RUNX1.

View Article and Find Full Text PDF

Because it accounts for 70% of all eye cancers, uveal melanoma (UM) is therefore the most common primary ocular malignancy. In this study, we investigated the molecular mechanisms leading to the aberrant expression of the gene encoding the serotonin receptor 2B (HTR2B), one of the most discriminating among the candidates from the class II gene signature, in metastatic and non-metastatic UM cell lines. Transfection analyses revealed that the upstream regulatory region of the gene contains a combination of alternative positive and negative regulatory elements functional in but not in ⁺ UM cells.

View Article and Find Full Text PDF

Psoriasis is a chronic inflammatory skin disease for which no cure has emerged. Its complex etiology requires the development of an in vitro model representative of the pathology. In this study, we exploited gene profiling analyses on microarray in order to characterize and further optimize the production of a human psoriatic skin model representative of this in vivo skin disease.

View Article and Find Full Text PDF