Publications by authors named "Maneewan Suksomtip"
Article Synopsis
- Cisplatin, a cancer treatment, causes cells to enter a state called senescence where they stop growing, and it also activates a protective response involving a protein called GRP78.
- In different types of lung cancer cells, the levels of GRP78 change: it helps some cancer cells survive and grow again after treatment, while in others, lower levels of GRP78 make them unable to escape this state.
- The study shows that GRP78 not only affects how cancer cells respond to treatment but also makes them resistant to a drug that targets aging cells, suggesting it plays a big role in cancer survival.
Context: Lentinus squarrosulus Mont. (Polyporaceae) is an interesting source of diverse bioactive compounds.
Objective: This is the first study of the anticancer activity and underlying mechanism of peptides extracted from Lentinus squarrosuls.
A citrate synthase (CS) deletion mutant of Agrobacterium tumefaciens C58 is highly attenuated in virulence. The identity of the mutant was initially determined from its amino acid sequence, which is 68% identical to Escherichia coli and 77% identical to Brucella melitensis. The mutant lost all CS enzymatic activity, and a cloned CS gene complemented a CS mutation in Sinorhizobium.
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