Publications by authors named "Mandy van Eldik"
Host Defence Peptides and derived peptides are promising classes of antimicrobial and immunomodulatory lead compounds. For this purpose we examined whether chicken cathelicidin-2 (CATH-2)-derived peptides modulate the function and inflammatory response of avian immune cells. Using a chicken macrophage cell line (HD11) we found that full-length CATH-2 dose-dependently induced transcription of chemokines CXCLi2/IL-8, MCP-3 and CCLi4/RANTES, but not of pro-inflammatory cytokine IL-1β.
View Article and Find Full Text PDFBackground: Virus neutralizing antibodies against respiratory syncytial virus (RSV) are considered important correlates of protection for vaccine evaluation. The established plaque reduction assay is time consuming, labor intensive and highly variable.
Methods: Here, a neutralization assay based on a modified RSV strain expressing the green fluorescent protein in combination with automated detection and quantification of plaques is described.
Article Synopsis
- Zinc is a crucial micronutrient for plants, and when they experience a deficiency, they adapt by increasing their ability to take up zinc.
- Researchers identified two transcription factors, bZIP19 and bZIP23, in the model plant Arabidopsis thaliana that play a key role in this adaptation.
- Mutations in both bZIP genes lead to severe sensitivity to zinc deficiency, showing these factors are essential for regulating the expression of genes necessary for zinc uptake.