Publications by authors named "Mandy Spaan"
Study Question: What is the risk of endometrial cancer after long-term follow-up in women treated with ART between 1983 and 2001 compared with women in the general population and subfertile women who did not undergo ART?
Summary Answer: The risk of endometrial cancer is not increased in women who underwent ART in the Netherlands between 1983 and 2001, neither compared with women from the general population nor compared with subfertile women not treated with ART.
What Is Known Already: Concerns have been raised that subfertility treatment may be associated with increased risk of endometrial cancer. However, published studies show inconsistent results regarding the effects of ovarian stimulation and specific subfertility diagnoses on endometrial cancer risk.
Article Synopsis
- The study investigates how health behaviors like smoking, physical inactivity, and alcohol use may mediate the relationship between depression, anxiety, and different types of cancer, including lung and breast cancer.
- Utilizing data from 18 cohorts with a total of 319,613 participants, the researchers performed two-stage meta-analyses to analyze these associations and calculate the mediating effects.
- Results showed that smoking and physical inactivity significantly mediated links between depression, anxiety, and lung cancer, highlighting the importance of smoking cessation programs for individuals dealing with mental health issues.
Article Synopsis
- The study investigates the role of psychosocial factors, like depression and anxiety, in how health behaviors (such as smoking and alcohol use) influence cancer incidence.
- Utilizing data from 437,827 participants and 22 cohorts, researchers performed meta-analyses to assess potential interactions between psychosocial factors and health behaviors across various types of cancer.
- Results showed no significant interactions or clear patterns; the risk of cancer linked to health behaviors appeared consistent regardless of the presence of psychosocial stress.
Since the introduction of Assisted Reproductive Technology (ART) in 1978, more than 10 million ART-conceived children have been born. Each phase of the ART procedure is substantially different from natural conception and these processes occur in the same timeframe as epigenetic programming. It seems plausible that ART could influence early stages of embryogenesis and thereby permanently influence the development and health of these individuals.
View Article and Find Full Text PDFBackground: The association between assisted reproductive technologies (ARTs) and the body mass index (BMI) of children remains controversial. Confounding by morbidity and other factors associated with parental infertility may have biased studies comparing children born after ART with children born after no treatment. We investigated the associations between different fertility treatments and BMI in children at age 5 to 8 years, adjusting for and stratifying by causes of parental infertility.
View Article and Find Full Text PDFArticle Synopsis
- Depression and anxiety have been studied as potential risk factors for various types of cancer, but previous research has produced inconclusive results.
- The PSY-CA consortium analyzed data from 18 cohorts, including over 319,000 participants, to investigate the relationship between these mental health conditions and cancer incidence using detailed statistical methods.
- The findings revealed no significant links between depression or anxiety and most cancer types, although there was a slight association with lung and smoking-related cancers, which diminished after accounting for other risk factors like smoking and alcohol consumption.
Study Question: Do children, adolescents, and young adults born after ART, including IVF, ICSI and frozen-thawed embryo transfer (FET), have an increased risk of cancer compared with children born to subfertile couples not conceived by ART and children from the general population?
Summary Answer: After a median follow-up of 18 years, the overall cancer risk was not increased in children conceived by ART, but a slight risk increase was observed in children conceived after ICSI.
What Is Known Already: There is growing evidence that ART procedures could perturb epigenetic processes during the pre-implantation period and influence long-term health. Recent studies showed (non-)significantly increased cancer risks after ICSI and FET, but not after IVF.
Background: There is concern that assisted reproductive technology (ART) may increase ovarian cancer risk, but previous studies are inconclusive. We compared ovarian cancer risk for women who gave birth after ART vs natural conception.
Methods: Through linkage of nationwide registry data, we followed 3,303,880 initially nulliparous women in Denmark (1994-2014), Finland (1990-2014), Norway (1984-2015) and Sweden (1985-2015) from first pregnancy ≥22 weeks to ovarian cancer, emigration, death or end of follow-up (2014/2015).
Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.
Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology.
Background: Long-term effects of assisted reproductive technology (ART) on ovarian tumor risk are unknown.
Methods: This nationwide cohort study comprises 30 625 women who received ovarian stimulation for ART in 1983-2000 and 9988 subfertile women not treated with ART. Incident invasive and borderline ovarian tumors were ascertained through linkage with the Netherlands Cancer Registry and the Dutch Pathology Registry until July 2018.
Study Question: Do children conceived by ART have an increased risk of cancer?
Summary Answer: Overall, ART-conceived children do not appear to have an increased risk of cancer.
What Is Known Already: Despite the increasing use of ART, i.e.
Importance: Previous studies of breast cancer risk after in vitro fertilization (IVF) treatment were inconclusive due to limited follow-up.
Objective: To assess long-term risk of breast cancer after ovarian stimulation for IVF.
Design, Setting, And Participants: Historical cohort (OMEGA study) with complete follow-up through December 2013 for 96% of the cohort.
Risk of Colorectal Cancer After Ovarian Stimulation for In Vitro Fertilization.
Clin Gastroenterol Hepatol
May 2016
Background & Aims: Apart from lifestyle factors, sex hormones also seem to have a role in the etiology of colorectal cancer. This raises interest in the possible effects of fertility drugs, especially because the use of ovarian stimulation for in vitro fertilization (IVF) has strongly increased over the past decades.
Methods: In 1996, a nationwide cohort study was set up to examine cancer risk in a population that included 19,158 women who received ovarian stimulation for IVF (IVF group) and 5950 women who underwent subfertility treatments other than IVF (non-IVF group).