Publications by authors named "Mandy M A Conijn"

The aims of this prospective diagnostic evaluation study were (i) to estimate the inter-observer agreement and reproducibility of real-time sonoelastography and real-time gray-scale ultrasound in the measurement of uterine and fibroid volumes; (ii) to evaluate the agreement between real-time gray-scale ultrasound, sonoelastography and magnetic resonance imaging with respect to these outcomes; and (iii) to evaluate the diagnostic accuracy of sonoelastography in the diagnosis of uterine pathology on stored sonoelastography and gray-scale cine loops. Women without a history of uterine pathology and with the diagnosis intrauterine fibroids or adenomyosis were included. All participants underwent gray-scale ultrasound, sonoelastography and magnetic resonance imaging.

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Article Synopsis
  • - The study aimed to determine if a new MRI technique, T2*-weighted fluid attenuation inversion recovery (FLAIR*), can distinguish between multiple sclerosis (MS) and vascular brain lesions at a high-resolution 7 Tesla MRI.
  • - The research included 16 MS patients and 16 patients with vascular disease risk factors, finding significantly more lesions in MS patients and noticeable differences in lesion characteristics such as orientation and rim presence.
  • - The use of 7-T FLAIR* not only increased the ability to differentiate between MS and vascular lesions but also highlighted the presence of central vessels in MS lesions more than in vascular lesions, indicating its diagnostic potential.
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Cerebral microbleeds (CMBs) are commonly detected on MRI and have recently received an increased interest, because they are associated with vascular disease and dementia. Identification and rating of CMBs on MRI images may be facilitated by semi-automatic detection, particularly on high-resolution images acquired at high field strength. For these images, visual rating is time-consuming and has limited reproducibility.

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The underlying pathology of lacunar infarcts, white matter lesions and also of microbleeds is poorly understood. We assessed whether the presence of lacunar infarcts, white matter lesions or microbleeds on MRI was associated with a decrease in cerebrovascular reactivity, and assessed whether this association was similar for lacunar infarcts, white matter lesions and microbleeds. BOLD-fMRI scan with breath-holding at 7 T and anatomical scans at 1.

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Background And Purpose: Cerebral small vessel disease may be related to vascular and nonvascular pathology. We assessed whether lacunar infarcts and white matter lesions on MRI increased the risk of vascular and nonvascular death and future vascular events in patients with atherosclerotic disease.

Methods: Brain MRI was performed in 1309 patients with atherosclerotic disease from the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study.

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Purpose: To assess the visualization of cerebral microbleeds with dual echo T2*-weighted imaging at 7.0 T magnetic resonance imaging (MRI).

Materials And Methods: Ten consecutive participants (eight men, two women, mean age 54 +/- 12 years) with vascular disease or risk factors from the second manifestations of arterial disease (SMART) study were included.

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The aim of this study was to investigate the ability of time-of-flight (TOF) magnetic resonance (MR) angiography at 7.0 Tesla to show the perforating branches of the posterior communicating artery (PCoA), and to investigate the presence of such visible perforating branches in relation to the size of the feeding PCoA. The secondary aim was to visualise and describe the anterior choroidal artery and the perforating branches of the P1-segment of posterior cerebral artery (P1).

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