Efficacy and safety of transdermal methimazole in the treatment of cats with hyperthyroidism.

The objective of this study was to determine whether transdermal methimazole was as safe and effective as oral methimazole for the control of hyperthyroidism in cats. Forty-seven cats with newly diagnosed hyperthyroidism were randomized to receive either transdermal methimazole in pluronic lecithin organogel (PLO; applied to the inner pinna), or oral methimazole (2.5 mg q12h for either route).

Efficacy and safety of once versus twice daily administration of methimazole in cats with hyperthyroidism.

Objective: To determine whether once daily administration of methimazole was as effective and safe as twice daily administration in cats with hyperthyroidism.

Design: Randomized, nonblinded, clinical trial.

Animals: 40 cats with newly diagnosed hyperthyroidism.