Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development.

Type 2 immune cells and eosinophils are transiently present in the lung tissue not only in pathology (allergic disease, parasite expulsion) but also during normal postnatal development. However, the lung developmental processes underlying airway recruitment of eosinophils after birth remain unexplored. We determined that in mice, mature eosinophils are transiently recruited to the lung during postnatal days 3-14, which specifically corresponds to the primary septation/alveolarization phase of lung development.