Publications by authors named "Mandy A Louderback"
Carcinogenesis
October 2006
Article Synopsis
- * Pregnant mice that consumed I3C showed significantly lower mortality rates and fewer lung tumors in their offspring compared to those that didn't receive the supplement.
- * The findings suggest that incorporating chemoprotective agents like I3C into the diets of pregnant women could be a promising strategy to lower cancer risks in future generations.
Article Synopsis
- Lymphoma and leukemia are the most frequent cancers in children and young adults, possibly linked to maternal exposure to environmental carcinogens during pregnancy.
- Pregnant mice exposed to dibenzo[a,l]pyrene (DBP) resulted in high mortality rates in their offspring due to aggressive T-cell lymphoblastic lymphoma and associated lung and liver tumors.
- The study highlights the importance of the aryl hydrocarbon receptor (AHR) in cancer susceptibility, indicating that PAH exposure during pregnancy may increase cancer risks in children, warranting further investigation.
