Publications by authors named "Mandelbaum R"
Article Synopsis
- - The study evaluated trends and outcomes of gestational carrier (GC) pregnancies in the U.S. using data from over 14 million deliveries between 2017 and 2020, finding that the prevalence of GC pregnancies rose by 55% during this period.
- - Among GCs, there was a higher likelihood of complications such as multiple pregnancies, placental abruption, and low-lying placenta, along with increased risks for late-preterm deliveries and postpartum hemorrhage in singleton births compared to non-GCs.
- - While GC pregnancies are relatively rare, the findings indicate they are becoming more common and generally have favorable pre-pregnancy characteristics, but their obstetric outcomes can be mixed, especially regarding certain complications. *
Article Synopsis
- Programmed or medicated frozen embryo transfer relies on the use of exogenous progesterone (P) to prepare the uterus for embryo implantation and to support pregnancy.
- The study highlights gaps in knowledge regarding the best dosage and method for administering P, as well as a lack of understanding of how P functions during implantation and pregnancy.
- The authors advocate for more research to better determine the ideal levels of both total and free P in the bloodstream and uterus, and how these levels impact womb readiness and pregnancy success.
Article Synopsis
- Pre-patterning in embryo development is common in non-mammalian species, but mammals were thought to lack this due to their regulative development, which randomly contributes to the three blastocyst lineages.
- Recent studies show that early blastomeres in mouse and human embryos actually have distinct developmental fates and differences in protein levels, challenging the previous notion of randomness.
- Utilizing advanced proteomics, researchers found that 2-cell embryos contain alpha and beta blastomeres with different protein abundances linked to their developmental potential, with beta blastomeres more likely to produce higher amounts of epiblast cells.
In this nationwide cross‐sectional study in the United States, clinical and gynecologic characteristics varied across the anatomical site of ectopic pregnancy.
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- Advancements in assisted reproductive technology have led to a rise in gestational carrier pregnancies, highlighting the need for more research on their perinatal outcomes and associated risks.
- The objective of the study was to analyze maternal characteristics and obstetric outcomes in pregnancies involving gestational carriers.
- A systematic review included six studies analyzing over 28,000 GC pregnancies, revealing higher rates of frozen embryo transfers and comparing various obstetric outcomes with non-GC pregnancies.
Article Synopsis
- The study aimed to find the best letrozole regimen for inducing ovulation in women with polycystic ovary syndrome (PCOS).
- Conducted at a single fertility clinic between 2015 and 2022, it analyzed 189 ovulation induction cycles among 52 women with PCOS.
- Results showed that higher doses and longer regimens (5 mg for 10 days or similar) significantly improved ovulation rates and reduced time to pregnancy compared to the standard regimen.
Article Synopsis
- A study was conducted to analyze obstetric outcomes in pregnant women with congenital uterine anomalies using data from the Nationwide Inpatient Sample between 2016 and 2019.* -
- Out of 50,180 women assessed, the majority had a bicornuate uterus, with 70.6% achieving full-term live births, while 26.8% experienced preterm births.* -
- The findings highlighted that women with uterine didelphys had the highest rates of preterm births, and 65.7% of all patients underwent cesarean sections, with increased risks of severe maternal morbidity associated with septate uteri.*
Objective: To examine pregnancy characteristics and maternal morbidity at delivery among pregnant patients with a diagnosis of endometriosis.
Study Design: This cross-sectional study queried the Healthcare Cost and Utilization Project's National Inpatient Sample. Study population was 17,796,365 hospital deliveries from 2016 to 2020, excluded adenomyosis and uterine myoma.
Objective: To describe population-level utilization of fertility-sparing surgery and outcome of reproductive-aged patients with early epithelial ovarian cancer who underwent fertility-sparing surgery in the United States.
Methods: This retrospective study queried the National Cancer Institute's Surveillance, Epidemiology, and End Result Program. The study included 3,027 patients younger than age 50 years with stage I epithelial ovarian cancer receiving primary surgical therapy from 2007 to 2020.
Retrospective lineage reconstruction of humans predicts that dramatic clonal imbalances in the body can be traced to the 2-cell stage embryo. However, whether and how such clonal asymmetries arise in the embryo is unclear. Here, we performed prospective lineage tracing of human embryos using live imaging, non-invasive cell labeling, and computational predictions to determine the contribution of each 2-cell stage blastomere to the epiblast (body), hypoblast (yolk sac), and trophectoderm (placenta).
View Article and Find Full Text PDFBackground: Although hysteropexy has been used to preserve the uterus during uterine prolapse surgery for a long time, there is a scarcity of data that describe the nationwide patterns of use of this surgical procedure.
Objective: This study aimed to examine the national-level use and characteristics of hysteropexy at the time of laparoscopic apical suspension surgery for uterine prolapse in the United States.
Study Design: This cross-sectional study used data from the Healthcare Cost and Utilization Project's Nationwide Ambulatory Surgery Sample.
Article Synopsis
- The study aimed to evaluate trends and outcomes of pregnancies in women with Turner syndrome in the U.S. using data from hospital deliveries between 2016 and 2020.
- Turner syndrome prevalence among pregnant patients was found to be 7.0 per 100,000 deliveries, with an increase in cases during the study period, suggesting a rising recognition of the condition.
- Pregnant women with Turner syndrome faced higher risks of various complications, such as pregestational hypertension, intrauterine fetal demise, and were more likely to have cesarean deliveries compared to those without the syndrome.
Purpose: To examine the utilization and characteristics related to the use of hysteroscopy at the time of endometrial evaluation for endometrial hyperplasia in the outpatient surgery setting.
Methods: This cross-sectional study queried the Healthcare Cost and Utilization Project's Nationwide Ambulatory Surgery Sample. The study population was 3218 patients with endometrial hyperplasia who underwent endometrial evaluation from January 2016 to December 2019.
Article Synopsis
- The study investigates the maternal and fetal health outcomes in morbidly obese pregnant women who conceived using assisted reproductive technology (ART), focusing on data from a significant national sample.
- It finds that patients with class III obesity (severe obesity) are at a notably higher risk for complications like hypertensive disorders, diabetes, and adverse neonatal outcomes compared to non-obese patients.
- Overall, the research indicates that severe obesity in pregnancy is linked to an increased likelihood of severe maternal morbidity, highlighting the need for tailored healthcare interventions for this population.
Article Synopsis
- Gallstone disease is a common reason for nonobstetrical surgery during pregnancy, but there's limited national data on current surgical practices and outcomes.* -
- The study analyzed data from 18,630 patients who underwent cholecystectomy during pregnancy between 2016 and 2020, focusing on different gestational age groups and their associated medical characteristics and outcomes.* -
- Findings revealed that early second trimester had the highest surgery rate, with distinct health issues identified in different trimesters, such as older age and smoking in the first trimester, and obesity and gestational diabetes in the third trimester.*
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women, affecting up to 15% of reproductive-aged women. Polycystic ovarian syndrome is a heterogeneous disorder, both in the sense that many different factors may play a role in its manifestation and that multiple systems throughout the body can be affected. Polycystic ovarian syndrome has been linked to an increased prevalence of various psychiatric disorders, including depression and anxiety.
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