Prenatal desvenlafaxine induced behavioural alterations in Swiss albino mice.

Background: Desvenlafaxine is used as an antidepressant and acts by inhibiting reuptake of serotonin and nor-adrenaline.

Purpose: The safety profile of desvenlafaxine has not yet been established during pregnancy, so we planned this study to see the behavioral changes in pups of mice who received desvenlafaxine during gestational period.

Methods: Swiss albino mice were used for the present study.

Effect of folic acid in prenatal alcohol induced behavioral impairment in Swiss albino mice.

Background: Alcohol is a potent teratogen inducing oxidative stress as well as a massive wave of apoptosis in the developing brain as well as oxidative stress. It affects brain including cerebellum, hippocampus and cerebral cortex resulting into motor and cognitive deficits. Alcohol depletes folic acid from the body which is essential for synthesis of DNA, RNA and protein during cell division and proved to prevent many brain related malformations.

Intranasal curcumin and its evaluation in murine model of asthma.

Curcumin, a phytochemical present in turmeric, rhizome of Curcuma longa, has been shown to have a wide variety of pharmacological activities including anti-inflammatory, anti-allergic and anti-asthmatic properties. Curcumin is known for its low systemic bioavailability and rapid metabolization through oral route and has limited its applications. Over the recent decades, the interest in intranasal delivery as a non-invasive route for drugs has increased as target tissue for drug delivery since nasal mucosa offers numerous benefits.

Chemotaxonomic variability in Zizyphus mouritiana varieties and its pharmacological properties in relation to human health.

Twenty varieties of ber (Zizyphus mouritiana), namely umaran, katha, bilayati, kaithli, ZG-3, gola, safeda rohtak, takadi, tikari, banarasi karaka, seo, sonaur-2, sonaur-3, ilaichi, mundia murahra, pathan, kakrola gola, seb, golden yellow and chhuhara, were investigated for the presence of phenolic acids in stem bark, leaves and fruits using high performance liquid chromatograph. Results indicated the presence of tannic (retention time (Rt.) 2.

Investigation on the phenolics of some spices having pharmacotherapeuthic properties.

Spices are an important group of agricultural commodities being used by many civilizations all over the world to aid flavor, taste and nutritional values in the food. In traditional medical systems, their ability to heal various physical, mental and emotional problems has widely been reported. With this view, HPLC analysis was performed to estimate phenolic acids in 21 spices (asafetida, Bishop's weed, black mustard, coriander, cinnamon, clove, curry leaf, cumin black, cumin, fennel, fenugreek, garlic, ginger, Indian cassia, Indian dill or dill large cardamom, onion, saffron, tamarind, true cardamom, yellow mustard) commonly used in India in different forms.

Characterization of phenolic compounds in some Indian mango cultivars.

Mangoes (Mangifera indica) are rich in phenolic acids as detected by high-performance liquid chromatography. The phenolics have prominent medicinal properties. Among six important commercial mango cultivars (Deshi, Langra, Chausa, Mallika, Dashahari and Amrapali) tannic acid was maximal in Mallika, while gallic acid was maximal in Chausa and all other varieties.

Conjoined twins cephalopagus janiceps monosymmetros: a case report.

Background: We present an extremely rare case of Janiceps type of female cephalopagus conjoined twins. Various pathological mechanisms that may be responsible for abnormal morphological development (limited to the conjoined part and normal morphological development in free lower abdomen and pelvis) are discussed.

Methods: Conjoined twins were obtained from a hospital, fixed in formalin, and dissected to observe and report the abnormalities present.

Effect of prenatal haloperidol exposure on behavioral alterations in rats.

Pregnant Charles-Foster rats were exposed to haloperidol (HAL), a neuroleptic drug that binds to and blocks dopamine (DA) receptor subtypes at a dose of 2.5 mg/kg body weight (intraperitoneally) from Gestation Day (GD) 12 to 20. The animals from both treated as well as vehicle control groups were allowed to deliver on GD 21.