Publications by authors named "Mandava P"

Machine Learning (ML) techniques require novel computer programming skills along with clinical domain knowledge to produce a useful model. We demonstrate the use of a cloud-based ML tool that does not require any programming expertise to develop, validate and deploy a prognostic model for Intracerebral Haemorrhage (ICH). The data of patients admitted with Spontaneous Intracerebral haemorrhage from January 2015 to December 2019 was accessed from our prospectively maintained hospital stroke registry.

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Introduction Aligning and leveling is the initial stage of comprehensive fixed orthodontic treatment aimed at minimizing the depth of the curve of Spee (COS). Various techniques exist to decrease the magnitude of the curve. This study investigates the skeletal and dental factors that reduce COS in individuals with minor class II malocclusions receiving nitinol (NiTi) wires with a reverse curve of Spee (RCS).

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Introduction Incorporation of remineralizing agents with fluoride-releasing bracket adhesives may prevent the development of white spot lesions (WSL) or reverse the established WSL in patients undergoing fixed orthodontic treatment. We aimed to find out how effectively casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride varnish (FV) can remineralize teeth when mixed with fluoride-releasing orthodontic adhesive. Materials and methods We randomly assigned a total of 60 premolar teeth, therapeutically extracted for orthodontic purposes, into two equal groups.

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  • A review was conducted on the impact of the ketogenic diet on epilepsy treatment in children and adolescents, following systematic guidelines and including 12 qualifying studies.
  • The ketogenic diet showed positive results in reducing the frequency and severity of seizures while presenting manageable side effects like gastrointestinal issues and dehydration.
  • Variations of the ketogenic diet were found beneficial for seizure management, serving as either a complementary or alternative treatment for young patients with epilepsy.
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Introduction:  Malocclusion has a psychological impact related to the patient's age. It also influences the quality of life. This research aims to test the null hypothesis that there is no association between the self-perceived psychosocial impacts of dental aesthetics with the severity of malocclusion, oral health-related quality of life (OHRQoL), and self-image of the body in young adults seeking orthodontic treatment.

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Objective: This study examined the glenoid fossa in Class II and Class III malocclusions with mandibular retrusion and protrusion.

Materials And Methods: A retrospective investigation examined 60 Class II and 60 Class III cephalometric radiographs. Cephalometric landmarks and glenoid fossa measurements were taken.

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  • The study looked at how a short dose of a medication called U-100 glargine (U-100G) affects people with type 1 diabetes when they switch to another medication called degludec.
  • They tested this on patients who were already using U-100G, by giving one group a dose of U-100G and the other group a placebo, and then checked their blood sugar levels.
  • Results showed that people using U-100G twice a day had better blood sugar control after switching to degludec when they received that short dose, compared to those who didn't.
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Background: Orthodontists, like any other medical professional, are susceptible to cumulative stressors and their undesirable consequences. The study aims to assess the self-perceived occupational stress levels and the psychological link between predictors and stress among orthodontic practitioners in India.

Materials And Methods: The participants in this cross-sectional study are active members of the Indian Orthodontic Society (IOS).

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Introduction: Bonding of brackets with adhesives during orthodontic fixed appliance therapy is associated with white spot lesions (WSLs). An adhesive developed with an antimicrobial property is advantageous to prevent decalcification of the enamel surface. The current study assesses the antimicrobial and shear bond strength (SBS) characteristics of an experimental conventional orthodontic adhesive incorporated with different concentrations of nanoparticles (NPs) prepared from the leaves of and compares them with non-admixed conventional adhesive.

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Introduction: An effective space opening for band placement with minimal pain and gingival inflammation is a prime requisite during fixed orthodontic procedures. The study aimed to compare the effectiveness of two types of separators, elastomeric and Kansal, in the amount of space opening, pain perception elicited, and gingival inflammation.

Methods: A random split-mouth study was designed with 30 subjects undergoing fixed orthodontic treatment.

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Hyperdontia involving the premolar teeth can be single or multiple or even related to a syndrome. These are frequently encountered in permanent dentition, but their occurrence has ranged between 0.09 and 0.

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Introduction The objective of this observational study is to compare the dental and skeletal changes that occur following the release of incisor locking in class II division 2 patients in the decelerating phase of the adolescent growth spurt. Materials and methods Lateral cephalograms of 17 subjects with skeletal class II and division 2 malocclusion, taken at the pre-treatment (T1) and post-leveling and alignment (T2) phases, were analyzed. All these patients were treated with non-extraction methods in the initial stage.

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Background And Objectives: Structured and systematised checklists have been shown to prevent complications and improve patient care. We evaluated the implementation of systematic safety checklists in our neurocritical care unit (NCCU) and assessed its effect on patient outcomes.

Design/methods: This quality improvement project followed a Plan-Do-Study-Act (PDSA) methodology.

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Background: asthma, a chronic respiratory disease caused by inflammation and narrowing of the small airways in the lungs, is the most common chronic childhood disease. Prevalence of childhood asthma in the United States is 5.8%.

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Introduction The debonding procedures should restore the enamel surface to its pre-treatment state as much as possible after removing orthodontic attachments and all remaining adhesive remnants from the surface of the tooth. The orthodontic attachments are bonded commonly by a light-cured composite system. Light-cured glass ionomer cement has been developed as an alternative to the composite as a bonding agent for orthodontic brackets.

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Objectives: We sought to compare thrombolysis outcomes from the Costa Rican Stroke Registry Program (CRSRP) with published individual patient data from NINDS and CLOTBUST-ER trials using matching and outcome modeling from randomized clinical trials (RCTs).

Materials And Methods: A retrospective observational study matching subjects on baseline characteristics, from the CRSRP, the control arm of CLOTBUST-ER, and the interventional arm of NINDS trials. Day 7-10/discharge modified Rankin Score (mRS), and early mortality was compared between matched subjects.

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Background: Although first line therapies for essential tremor have been identified from small clinical trials, responses are variable. We conducted a survey of tremor management in a large sample of ET cases.

Methods: The Movement Disorders Clinical Case Registry within a US Veterans Health Administration medical center was used to identify 1468 patients with ET.

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Background: The purpose of this randomized trial is to compare the efficacy of weekly once regime of neutral sodium fluoride (NaF) oral rinse with that of acidulated phosphate (APF) formulated daily mouth rinse in the reduction of white spot lesions (WSLs) associated with fixed orthodontic appliance treatment.

Methods: The participants ( = 90) of this single-center, two-arm parallel study without a control group were randomly assigned with 1 : 1 distribution to each of the two groups after the bonding of brackets. Group A/test group 1 ( = 45) was given weekly rinse of neutral sodium fluoride (0.

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  • The study aimed to assess the retention practices of orthodontists in India through a questionnaire sent to members of the Indian Orthodontic Society.
  • The survey found that most orthodontists preferred dual retention approaches, with fixed retainers commonly used in the mandible and a combination of fixed and removable options favored in the maxilla.
  • A significant majority recommended full-time wear of maxillary retainers and suggested a duration of 2-5 years for fixed retainers.
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  • The study aimed to assess the safety and effectiveness of sonothrombolysis (ultrasound-enhanced thrombolysis) in patients experiencing acute ischemic stroke (AIS) caused by large vessel occlusion, using data from randomized controlled trials.
  • Out of 7 trials involving 1102 patients, those receiving sonothrombolysis showed a significantly higher rate of complete recanalization (40.3%) compared to those treated with standard intravenous thrombolysis (22.4%).
  • The risk of symptomatic intracranial hemorrhage was not significantly different between the two groups, and there were no notable differences in other outcomes like asymptomatic hemorrhage or functional independence at three months.
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Introduction: Enamel loss is a common problem during various orthodontic procedures. The study aims to compare the efficacy of a desensitizer and remineralizer in the reduction of the dentin hypersensitivity (DH) associated with enamel microcracks after orthodontic debonding.

Methods: A unicentric two arm parallel study with 30 subjects randomly assigned to each groups following debonding.

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Objective: The treatment protocol in the modern health care paradigm has shifted considerably towards enhancing the quality of life in the last decade. This is particularly important in cosmetic and elective treatments, and hence the interest in oral health-related quality of life (OHRQoL) also has increased. OHRQoL always been measured by endogenous, functional, social, or psychological determinants.

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  • The study aimed to examine how blood pressure (BP) spikes after receiving tissue plasminogen activator (tPA) influence the risk of intracranial hemorrhage (ICH) and functional recovery in patients with acute ischemic stroke (AIS).
  • In the analysis of 674 patients, about 34% experienced significant BP excursions (over 185 systolic/105 diastolic) within the first 24 hours post-treatment, primarily within the first 75 minutes.
  • Higher rates of these BP excursions correlated with worse outcomes, including lower chances of independence after 90 days and higher likelihood of ICH, highlighting the need for careful BP monitoring after tPA administration.
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Every practicing orthodontist today is aware of the importance of considering arch form in the attainment of a functional orthodontic correction [1]. Arch perimeter or circumference prediction is an essential component when Tooth Size Arch Length Discrepancy (TSALD) is estimated. Arch perimeter is the distance from mesial contact of the permanent molar on one side to the mesial contact of the permanent molar on the other side, with the line connecting the buccal/incisor tip points in the intervening teeth.

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Background And Purpose: Blood pressure (BP) variability has been associated with worse neurological outcomes in acute ischaemic stroke (AIS) patients receiving treatment with intravenous thrombolysis (IVT). However, no study to date has investigated whether pulse pressure (PP) variability may be a superior indicator of the total cardiovascular risk, as measured by clinical outcomes.

Methods: Pulse pressure variability was calculated from 24-h PP measurements following tissue plasminogen activator bolus in AIS patients enrolled in the Combined Lysis of Thrombus using Ultrasound and Systemic Tissue Plasminogen Activator for Emergent Revascularization (CLOTBUST-ER) trial.

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