Combination of neoadjuvant and adjuvant chemotherapy with FOLFOX compared with adjuvant chemotherapy in management of locally advanced rectal cancers: a randomized trial of a promising therapeutic approach.

Background: Colorectal cancer (CRC) is a significant malignancy with widespread implications. Despite progress in surgical interventions for rectal cancer, improvements in overall prognosis remain disproportionate. Standard preoperative chemoradiation, while established as the standard treatment for the majority of rectal cancers, exhibits limited effectiveness in enhancing disease-free survival (DFS) and mitigating distant metastases, particularly in cases of locally advanced rectal cancer (LARC).

Validation of an individualized home-made superficial brachytherapy mold applied for deep nonmelanoma skin cancer.

Background: This study was conducted to evaluate the effect of brachytherapy (BT) customized mold [Condensation silicone elastomer (Protesil)] and its thickness on the dose distribution pattern of deep nonmelanoma skin cancers (NMSC).

Materials And Methods: Four blocks of mold material were constructed in 5, 10, 15, and 20 mm thickness and 100 × 100 mm area by a plastic cast. The high dose rate (HDR) plus treatment planning system (TPS) (Version 3, Eckert & Ziegler BEBIG Gmbh, Berlin, Germany) with a Co source (model: Co0.