ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis.

Triple-negative breast cancer (TNBC) has profound unmet medical need globally for its devastating clinical outcome associated with rapid metastasis and lack of targeted therapies. Recently, lipid metabolic reprogramming especially fatty acid oxidation (FAO) has emerged as a major driver of breast cancer metastasis. Analyzing the expression of major FAO regulatory genes in breast cancer, we found selective overexpression of acyl-CoA synthetase 4 (ACSL4) in TNBC, which is primarily attributed to the absence of progesterone receptor.

Identification of pathogenicity determinants in ToLCNDV and their RNAi-based knockdown for disease management in and tomato plants.

(tomato leaf curl New Delhi virus, ToLCNDV), is member of the genus , family , is a prolific bipartite whitefly transmitted begomovirus in the Indian sub-continent has a wide host range, including solanaceous, cucurbitaceous and other plants. Recently, dsRNA-mediated non-transgenic approaches have been promising in managing plant viruses. Such an approach could be effective if the pathogenicity determinants of a virus are targeted.

Recent advances in platelet-rich plasma and its derivatives: therapeutic agents for tissue engineering and regenerative medicine.

Platelet rich plasma (PRP) is a suspension of bioactive factors and chemokine enriched plasma. Platelets are a distinctive source of membrane bound and soluble proteins that are released upon their activation. The higher count of platelets renders PRP with an array of tissue regenerative abilities.

Morphology Transition of Tripeptides from Porous Spherical to Rod-like Nanostructures for Small-Molecule Adsorption.

Peptides possess a remarkable propensity to adopt distinct morphologies, ranging from simple aggregates to complex structures such as fibrils and nanotubes. Morphology transformation in peptides is intricately linked to the physicochemical properties of peptides and external factors such as pH, temperature, and solvent conditions. Thus, it is more complex.

A Critical Assessment of Boundary Limits of Health Risks Associated with WBV Exposure Based on Field Studies on LHD Vehicles in Indian Underground Coal Mines.

Purpose: The mining sector plays a pivotal role in meeting global resource demands, necessitating the extensive use of heavy earth-moving machinery (HEMM). Among these, load-haul-dump (LHD) mining vehicles are vital but expose operators to whole-body vibration (WBV) and shocks during their duties. Research indicates potential health risks associated with occupational WBV exposure, including musculoskeletal disorders.

Pyrochlore-like Local Structure in Globally Disordered YZrO: Evidence and Reasoning by Combined Theoretical and Experimental Study.

Even though technological relevance for nuclear and oxide fuel cell application has persuaded a large number of investigations on the YZrO system, its local structure still remains ambiguous and debatable. While diffraction-based investigations claim a lack of local ordering, the MAS NMR and Raman spectroscopic investigations speculate the presence of local ordering. Besides, a correlation between the local and global structures of YZrO is also missing to date.

CO selectivity and adsorption performance of KCO-modified zeolite: a temperature-dependent study.

High-performing zeolite materials for carbon dioxide capture are promising for applications such as flue gas CO capture. Potassium carbonate-loaded zeolites can offer a plethora of benefits. In this work, for the first time, zeolite-Y impregnated with KCO was studied as a gas adsorbent (CO, CH, and N) and characterized using TGA (thermogravimetric analyzer), XRD, BET, FTIR, FETEM (Field-Emission Transmission Electron Microscope), and XPS.

Immobilized Horseradish Peroxidase on Enriched Diazo-Activated Silica Gel Harnessed High Biocatalytic Performance at a Steady State in Organic Solvent.

Dimethyldichlorosilane (DMDCS), an efficient silane coupling reagent appearing between the -OH groups of silica gel (SG) and picric acid, instantaneously produces a derivative enriched with nitro groups. The nitro group acting as an end-cap terminates the reaction and subsequently was converted into diazo to couple tyrosine's phenol ring via its -carbon, the inert center to immobilize horseradish peroxidase (HRP) in a multipoint mode. It maintains the status quo of the native enzyme's protein folding and the entire protein groups' chemistry.

Association between sleep quality, sleep duration, and physical frailty among adults aged 50 years and older in India.

Background: Considering the significant growth in India's aging population, it is imperative to identify factors associated with frailty among older Indians. This study examined the association between sleep quality, sleep duration, and physical frailty among older adults in India. Moreover, we examined whether the associations between sleep quality, sleep duration, and physical frailty varied by gender.

Different metal-doped NiO nanoparticles for sunlight-mediated degradation of low-density polyethylene microplastic films.

Due to the widespread use and incorrect handling of plastics, we need to find a practical and effective way to eliminate plastic waste from the environment. Different metal-doped nickel oxide (DMD-NiO) nanoparticles (NPs) were synthesized using a sol-gel technique and were used to degrade low-density polyethylene (LDPE) microplastic (MP) films when exposed to sunlight. The optical and structural properties of sol-gel method synthesized materials were investigated using a variety of characterization methods (Fourier transform infrared (FT-IR), UV-vis diffuse reflectance spectroscopy (UV-vis DRS), X-ray diffractometer (XRD) analysis, X-ray photoelectron spectroscopy (XPS), high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) analysis, and thermogravimetric analysis (TGA).

Silk-hydrogel functionalized with human decellularized Wharton's jelly extracellular matrix as a minimally invasive injectable hydrogel system for potential nucleus pulposus tissue replacement therapy.

Intervertebral disc degeneration is a primary cause for chronic low back pain, a common health problem with high incidence and the leading cause of disability globally. The early stages of disc degeneration in terms of functional and anatomical abnormalities start from the central nucleus pulposus tissue of the intervertebral disc; hence its regeneration has become a prime concern. A plethora of hydrogel systems have been investigated as nucleus pulposus tissue substitute over the years, with limited clinical translation.

Mixed quantum/classical theory for rotationally inelastic scattering of identical collision partners revised.

Mixed quantum/classical theory (MQCT) for the treatment of rotationally inelastic transitions during collisions of two identical molecules, described either as indistinguishable or distinguishable partners, is reviewed. The treatment of two molecules as indistinguishable includes symmetrization of rotational wavefunctions, introduces exchange parity, and leads to state-to-state transition matrix elements different from those in the straightforward treatment of molecules as distinguishable. Moreover, the treatment of collision partners as indistinguishable is eight times faster.

Development of infectious clones of mungbean yellow mosaic India virus (MYMIV, Begomovirus vignaradiataindiaense) infecting mungbean [Vigna radiata (L.) R. Wilczek] and evaluation of a RIL population for MYMIV resistance.

Yellow mosaic disease (YMD) is a major constraint for the low productivity of mungbean, mainly in South Asia. Addressing this issue requires a comprehensive approach, integrating field and challenge inoculation evaluations to identify effective solutions. In this study, an infectious clone of Begomovirus vignaradiataindiaense (MYMIV) was developed to obtain a pure culture of the virus and to confirm resistance in mungbean plants exhibiting resistance under natural field conditions.

A smart adaptable metal sequestering peptide conjugate to modulate Aβ fibrillar aggregation.

The aggregation of amyloid β peptide (Aβ) in the presence of elevated levels of transition-metal ions, , Fe, Cu, Zn, is accountable for enhanced cellular toxicity in Alzheimer's disease. Many strategies are reported to inhibit either Cu, Zn, or Fe-induced Aβ fibrillation, focused on one metal. Herein, a taurine-containing adaptable metal sequestering peptide (AMSP) has been developed as the modulator of any of the cited metal-induced Aβ-aggregation .

Mesenchymal Stem Cell-Conditioned Media-Loaded Microparticles Enhance Acute Patency in Silk-Based Vascular Grafts.

Coronary artery disease leads to over 360,000 deaths annually in the United States, and off-the-shelf bypass graft options are currently limited and/or have high failure rates. Tissue-engineered vascular grafts (TEVGs) present an attractive option, though the promising mesenchymal stem cell (MSC)-based implants face uncertain regulatory pathways. In this study, "artificial MSCs" (ArtMSCs) were fabricated by encapsulating MSC-conditioned media (CM) in poly(lactic-co-glycolic acid) microparticles.

Peptide-Based Strategies: Combating Alzheimer's Amyloid β Aggregation through Ergonomic Design and Fibril Disruption.

Amyloidosis of amyloid-β (Aβ) triggers a cascade of events, leading to oxidative damage and neuronal death. Therefore, inhibiting Aβ amyloidosis or disrupting the matured fibrils is the primary target to combat progressive Alzheimer's disease (AD) pathogenesis. Here, we undertake optimization strategies to improve the antiamyloid efficiency of our previously reported NF11 (NAVRWSLMRPF) peptide.

Ultrasmall CsPbBr Nanocrystals as a Recyclable Heterogeneous Photocatalyst in 100% - and Anti-Markovnikov Sulfinylsulfonation of Terminal Alkynes.

The precise synthesis of ultrasmall, monodisperse CsPbBr nanocrystals is crucial due to their enhanced photophysical properties resulting from strong quantum confinement effects. Traditional methods struggle with size control, complicating synthesis. Although CsPbBr nanocrystals find applications in LEDs and photovoltaics, their use in photocatalysis for organic reactions remains limited.

Rotation insensitive implantable wireless power transfer system for medical devices using metamaterial-polarization converter.

This article introduces an innovative approach for creating a circular polarization (CP) antenna-based rotation-insensitive implantable wireless power transfer (WPT) system for medical devices. The system is constructed to work in the industrial, scientific, and medical (ISM) frequency band of 902-928 MHz. Initially, a flexible, wide-band, and bio-compatible open-ended CP slot antenna is designed within a single-layer human skin tissue model to serve as the receiving (Rx) element.

Cerium-based metal-organic-frameworks with ligand tuning of the microstructures for fluoride adsorption: linear and nonlinear kinetic and isotherm adsorption models.

We present the synthesis and characterisation of three Ce-based metal-organic frameworks (Ce-MOFs) using fumaric acid (Fu), terephthalic acid (BDC), and trimesic acid (HBTC) as linkers. The use of different linkers influenced the size of the MOF particles, surface area, crystallinity, and microporous structure. The successful implementation of Ce-Fu, Ce-BDC, and Ce-HBTC MOFs for fluoride ion removal from wastewater was carried out, in which Ce-Fu MOFs exhibited a maximum adsorption capacity (AC) of 64.

Activation of Inert Supports for Enzyme(s) Immobilization Harnessing Biocatalytic Sustainability for Perennial Utilization.

Although Nature's evolution and intelligence have gifted humankind with noteworthy enzyme candidates to simplify complex reactions with ultrafast, overselective, effortless, mild biological reactions for millions of years, their availability at minute-scale, short-range time-temperature stability, and purification costs hardly justify recycling/or reuse. Covalent immobilization, particularly via multipoint bonds, prevents denaturing, maintains activities for long-range time, pH, and temperature, and makes catalysts available for repetitive usages; which attracts researchers and industries to bring more immobilized enzyme contenders in science and commercial progressions. Inert-support activation, the most crucial step, needs appropriate activators; under mild conditions, the activator's functional group(s) still present on the activated support rapidly couples the enzyme, preventing unfolding and keeping the active site alive.