Publications by authors named "Manda Markanovic"

Due to the limited treatment options and increased mortality rates, infection prevention and control strategies have been implemented for many years to mitigate dissemination of vancomycin-resistant enterococci (VRE) within healthcare settings. The overview provides an insight into the most recent research, particularly the pathogen's resilience in the healthcare environment, and the critical need for infection control strategies, which are currently being scrutinized by some researchers. The notable resilience of enterococci to various environmental conditions highlights the necessity for investigations into innovative technologies capable of effectively targeting the biofilm produced by enterococci on hospital surfaces.

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Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Although the oral cavity is an easily accessible area for visual examination, the OSCC is more often detected at an advanced stage. The global prevalence of OSCC is around 6%, with increasing trends posing a significant health problem due to the increase in morbidity and mortality.

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We evaluated the performance of Zybio EXS2600 matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) (Zybio Inc., Chongqing, China) for the identification of bacteria from positive blood culture (BC) bottles using Blood Culture Positive Sample Pretreatment Kit (Zybio Inc., Chongqing, China) in comparison to an in-house saponin method.

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Article Synopsis
  • Major challenges in identifying non-tuberculous mycobacteria (NTM) using MALDI-TOF MS include the need for better protein extraction methods and keeping the database up-to-date.
  • The study evaluated the effectiveness of MALDI Biotyper Mycobacteria Library v6.0 in accurately identifying NTM isolates from clinical samples, using PCR-reverse hybridization as a reference.
  • Findings showed that MALDI-TOF MS achieved a 94.06% correct identification rate, with most results being high-confidence, indicating that this method can enhance understanding of the clinical implications related to rare NTM species.
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