Publications by authors named "Manchun Li"

Despite gut microbiota-derived extracellular vesicles (EVs) serving as pivotal mediators in bacteria-host cell interactions, their potential role in modulating skin inflammation remains poorly understood. Here, we developed strategies for mass production of Parabacteroides goldsteinii-derived outer membrane vesicles (Pg OMVs), commonly known as EVs. We found that orally administered Pg OMVs can reach the colon, traverse the intestinal barrier, and circulate to the inflamed skin of psoriasis-like mice, resulting in reduced epidermal hyperplasia, suppressed infiltration of inflammatory cells in the skin lesions, and effective amelioration of both skin and systemic inflammation.

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Forest biomass carbon (BC) storage is an important means of mitigating climate change. However, the spatiotemporal patterns and stability of BC growth remain unclear in China. Based on the latest BC maps (2002-2021), we calculated the spatiotemporal dynamics of BC and used resilience indicators to reveal the stability of BC.

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Background: The function of hematopoietic stem cells (HSC) is regulated by HSC internal signaling pathways and their microenvironment. Chemokines and chemokine ligands play important roles in the regulation of HSC function. Yet, their functions in HSC are not fully understood.

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Crop residue burning (CRB) is a major contributor to air pollution in China. Current fire detection methods, however, are limited by either temporal resolution or accuracy, hindering the analysis of CRB's diurnal characteristics. Here we explore the diurnal spatiotemporal patterns and environmental impacts of CRB in China from 2019 to 2021 using the recently released NSMC-Himawari-8 hourly fire product.

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Selenium (Se) is an essential micronutrient that is both hazardous and beneficial to living organisms. However, few studies have examined soil Se distribution and its driving mechanisms on a large basin scale. Thus, multivariate statistics, geostatistics, boosted regression trees, and structural equation models were used to investigate the spatial distribution, driving factors, and multivariate interactions of soil Se based on 1753 topsoil samples (0-20 cm) from the Taihu Lake Basin.

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Article Synopsis
  • Existing treatments for autoimmune diseases are often ineffective and have serious side effects, which complicates targeted treatment.
  • Researchers have created multifunctional fusion nanovesicles using grapefruit-derived exosomes and engineered stem cell membranes to effectively deliver an immunosuppressant drug called CX5461 directly to inflamed tissue.
  • The new nanovesicles, FV@CX5461, show great promise in treating skin conditions like psoriasis and atopic dermatitis by reducing inflammation and restoring immune balance.
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Causal inference in complex systems has been largely promoted by the proposal of some advanced temporal causation models. However, temporal models have serious limitations when time series data are not available or present insignificant variations, which causes a common challenge for earth system science. Meanwhile, there are few spatial causation models for fully exploring the rich spatial cross-sectional data in Earth systems.

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Ultraviolet Imager (UVI) onboard Haiyang-1C/D (HY-1C/D) satellites has been providing ultraviolet (UV) data to detect marine oil spills since 2018. Although the scale effect of UV remote sensing has been preliminarily interpreted, the application characteristics of spaceborne UV sensors with medium spatial resolution in oil spill detection deserve further investigation, especially the role of sunglint in the process of detection. In this study, the performance of the UVI is thoroughly assessed by the following aspects: image features of oils under sunglint, sunglint requirement for spaceborne UV detection of oils, and the stability of the UVI signal.

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Urban vitality is the comprehensive form of regional development quality, sustainability, and attractiveness. Urban vitality of various regions within the cities has difference, and the quantitative evaluation of urban vitality within the cities can help guide to future city constructions. Evaluation of urban vitality needs the combination of multi-source data.

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Understanding interactions between bone morphogenetic proteins (BMPs) and biomaterials is of great significance in preserving the structure and bioactivity of BMPs when utilized in clinical applications. Currently, bone morphogenetic protein-2 (BMP-2) is one of the most important growth factors in bone tissue engineering; however, atomistic interactions between BMP-2 and zinc-substituted hydroxyapatite (Zn-HAP, commonly used in artificial bone implants) have not been well clarified until now. Thus, in this work, the interaction energies, binding/debinding states, and molecular structures of BMP-2 upon a series of Zn-HAP surfaces (Zn-HAPs, 1 at%, 2.

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The rapid development of economy and society leads to the rapid expansion of cities, resulting in the atrophy of urban ecological space and the decline of ecological function, as well as a serious threat to urban ecological security. It is of great significance for the sustainable development of a city to systematically analyze the structure of urban ecological space and put forward targeted protection and optimization measures. Taking Changzhou City as the research area and considering the natural ecological function and social service function of urban ecological space, we constructed two ecological networks, the "source-corridor" ecological network based on natural ecology and the "supply-demand" ecological network based on human ecology.

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Urban environments, regarded as "harbingers" of future global change, may exert positive or negative impacts on urban vegetation growth. Because of limited ground-based experiments, the responses of vegetation to urbanization and its associated controlling factors at the global scale remain poorly understood. Here, we use satellite observations from 2001 to 2018 to quantify direct and indirect impacts of urbanization on vegetation growth in 672 worldwide cities.

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Land use change driven by human activities plays a critical role in the terrestrial carbon budget through habitat loss and vegetation change. Despite the projections of the global population and economic growth under the framework of the Shared Socioeconomic Pathways (SSPs), little is known of land use/cover change (LUCC) at a fine spatial resolution and how carbon pools respond to LUCC under different SSPs. This study projected the future global LUCC with 1 km spatial resolution and a 10-year time step from 2010 to 2100 and then explored its direct impacts on aboveground biomass carbon (AGB) under SSPs.

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Reliable attribution is crucial for understanding various climate change issues. However, complicated inner-interactions between various factors make causation inference in atmospheric environment highly challenging. Taking PM-Meteorology causation, which involves a large number of non-Linear and uncertain interactions between many meteorological factors and PM, as a case, we examined the performance of a series of mainstream statistical models, including Correlation Analysis (CA), Partial Correlation Analysis (PCA), Structural Equation Model (SEM), Convergent Cross Mapping (CCM), Partial Cross Mapping (PCM) and Geographical Detector (GD).

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Satellite-derived bathymetry (SDB) has an extensive prospect in nearshore bathymetry for its high efficiency and low costs. Atmospheric correction and bathymetric modeling are critical processes in SDB, and examining the performance of related algorithms and models will contribute to the formulation of reliable bathymetry strategies. This study explored the effectiveness of three general atmospheric correction algorithms, namely Second Simulation of a Satellite Signal in the Solar Spectrum (6S), Atmospheric correction for OLI 'lite' (ACOLITE), and QUick Atmospheric Correction (QUAC), in depth retrieval from Landsat-8 and Sentinel-2A images using different SDB models over Ganquan Island and Oahu Island.

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To promote coordinated development of the global economy, society, and environment, The 2030 Agenda for Sustainable Development of the United Nations (UN) specifies 17 sustainable development goals (SDGs) with 169 nested targets. Studies have shown that a healthy ecological environment and stable ecosystem services (ESs) provide an important foundation for achieving the SDGs. Due to the lack of quantitative methods for assessing the contribution of ESs to SDGs, very few empirical studies have been conducted to examine how knowledge of ESs can guide regional sustainable development.

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Background: Spatial allocation of medical resources is closely related to people's health. Thus, it is important to evaluate the abundance of medical resources regionally and explore the spatial heterogeneity of medical resource allocation.

Methods: Using medical geographic big data, this study analyzed 369 Chinese cities and constructed a medical resource evaluation model based on the grading of medical institutions using the Delphi method.

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Ecosystem services (ESs) link natural and social processes and play an important role in sustaining ecological security, human well-being, and sustainable development. However, uncertainties in future socioeconomic land use drivers may result in very different land use dynamics and consequences for land-based ESs. In this study, land use transitions in the Yangtze River Economic Belt (YREB) were simulated in the short term (2018-2030), medium term (2030-2040), and long term (2040-2050) using the future land use simulation (FLUS) model based on the local shared socioeconomic pathways (SSPs).

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Ground level ozone exerts a strong impact on crop yields, yet how to properly quantify ozone induced yield losses in China remains challenging. To this end, we employed a series of O-crop models to estimate ozone induced yield losses in China from 2014 to 2018. The outputs from all models suggested that the total Relative Yield Losses (RYL) of wheat in China from 2014 to 2018 was 18.

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Ongoing, rapid urban growth accompanied by habitat fragmentation and loss challenges biodiversity conservation and leads to decreases in ecosystem services. Application of the concept of ecological networks in the preservation and restoration of connections among isolated patches of natural areas is a powerful conservation strategy. However, previous approaches often failed to objectively consider the impacts of complex 3-D city environments on ecological niches.

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Airborne laser scanning (ALS) can acquire both geometry and intensity information of geo-objects, which is important in mapping a large-scale three-dimensional (3D) urban environment. However, the intensity information recorded by ALS will be changed due to the flight height and atmospheric attenuation, which decreases the robustness of the trained supervised classifier. This paper proposes a hierarchical classification method by separately using geometry and intensity information of urban ALS data.

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Farmland landscapes are intuitive indicators of the functions of farmland ecosystems. However, geographical differences complicate the spatio-temporal evolutionary characteristics of farmland landscape systems, making them difficult to explore. This creates a series of difficulties in designing farmland management policy in China's diversified geographical environment.

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Global warming and climate change have become a serious environmental problem and China's carbon emissions are currently the highest in the world. Cities are the main sources of carbon emissions and the key to solving these problems. Therefore, research on reducing carbon dioxide emissions is a matter of concern.

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