Publications by authors named "Manchanda S"

Background: Invasive fungal sinusitis (IFS) can present as a mild disease to life-threatening infection. A recent surge in cases was seen due to the coronavirus disease 2019 (COVID-19) pandemic. Many patients require surgical debridement and hence imaging [contrast-enhanced computed tomography (CECT) of the paranasal sinuses (PNS)] to document the extent of the disease.

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Malignant transformation of neurofibromas into malignant peripheral nerve sheath tumors (MPNST) is a rare but aggressive phenomenon, particularly in the head and neck region, and is associated with a poor prognosis. The primary treatment modality is surgical excision, often followed by radiotherapy. This is a case report of MPNST in the neck, with long-term follow-up.

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Clear cell tumors of parotid gland encompass a wide spectrum of neoplasms, including benign and malignant epithelial neoplasms. Additionally, tumors from adjacent structures such as paraganglioma, and metastatic neoplasms may also show clear cells. Overlapping cytological features may cause difficulty in diagnosis.

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Article Synopsis
  • HNS Treatment Context
  • : Hypoglossal nerve stimulation (HNS) is a viable treatment for moderate-to-severe obstructive sleep apnea, and post-implant procedures like awake endoscopy with advanced programming (AEAP) can enhance the effectiveness and comfort of this treatment.
  • Study Methods
  • : The study analyzed 17 patients who underwent AEAP to assess their apnea hypopnea index (AHI) responses, categorizing them into two groups based on their NT-AHI, using various statistical methods to determine significance.
  • Key Findings and Conclusion
  • : Most patients who initially struggled with NT-AHI reduction showed improvements after AEAP, particularly those without specific airway issues; the research emphasizes the importance of
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Article Synopsis
  • Challenging adherence to positive airway pressure (PAP) therapy in patients with allergic rhinitis was highlighted in a case study of a 62-year-old male with obstructive sleep apnea (OSA) who struggled with PAP for ten years.
  • The combination of daily intranasal oxymetazoline and fluticasone significantly improved his tolerance and adherence to PAP therapy, unlike using fluticasone alone.
  • This approach may help enhance CPAP tolerance in patients with OSA and rhinitis, offering a promising area for future exploration to improve treatment adherence.
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Objective: Candida is a common fungal pathogen in the oral cavity, with Candida albicans being the most prevalent species. Some studies report a correlation between Candida prevalence and dental caries experience in preschoolers, while others report no such association. This systematic review and meta-analysis aimed to evaluate the association of Candida-biome with Early Childhood Caries (ECC) in preschool children.

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 Accurate preoperative characterization of adnexal masses is essential for optimal patient management. Two-dimensional ultrasonography (USG) based "International Ovarian Tumuor Analysis Simple Rules (IOTA-SR)" are used primarily in clinical practice. Three-dimensional (3D) USG is an emerging modality.

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Objective: Hypoglossal nerve stimulation (HGNS) is an implantable therapy for obstructive sleep apnea (OSA). Therapy efficacy is currently confirmed by a formal sleep study after empiric adjustment by the patient at home based on their subjective experience with the device. Home-based longitudinal apnea hypopnea index (AHI) measurements have the potential to refine HGNS therapeutic amplitude selection with objective data.

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Objective(s): To evaluate and compare diagnostic performance of ultrasound-based reporting systems IOTA SR, ADNEX, GIRADS, ORADS for discrimination between benign and malignant adnexal masses.

Study Design: A prospective observational study in a tertiary care hospital's Obstetrics and Gynaecology department evaluated pre-operative ultrasound imaging for adnexal masses in 80 cases, comparing various reporting systems' sensitivity and specificity against histopathology as gold standard using STATA version 17.0 for data analysis.

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Background: Pre-vascular facial nodes (PV-FNs; perifacial lymph nodes) are supra-mandibular lymph nodes above the inferior border of the mandible. These are not part of routine neck dissection done for OCSCC. These lymph nodes can be sentinel station for metastatic lymph nodes from gingivobuccal complex cancers and are missed during routine neck dissection.

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Unlabelled: The use of acid suppression therapy (AST) is a common approach for managing a wide spectrum of acid peptic disorders. Histamine type 2-receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) are the most widely prescribed AST in routine clinical practice. However, an exponential surge in the prescriptions of PPIs, such as Omeprazole, Esomeprazole, Pantoprazole, Lansoprazole in recent years and their associated adverse effects have raised concern about their inappropriate and overuse, both in children and adults.

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Objective: Due to the controversy surrounding the appropriate outcomes in neurostimulation, we sought to systematically describe ways in which polysomnography and apnea-hypopnea index are reported in prospective studies involving unilateral hypoglossal nerve stimulation.

Data Sources: MEDLINE (Ovid), Embase (Ovid), Cochrane Library, and Scopus.

Review Methods: Following the Preferred Reporting items of Systematic Reviews and Meta-analysis (PRISMA) Statement guidelines, a systematic two-reviewer system was used for study screening and quality assessment.

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Study Objectives: Behavioral sleep medicine (BSM) is a subspecialty that combines behavioral psychology and sleep medicine specialties. The objective of this study was to analyze referral patterns to a BSM clinic. The 3 specific aims were: (1) describe factors that predict referral acceptance, (2) identify barriers to attending initial appointment, and (3) describe variables associated with the number of visits attended.

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This review is intended to familiarize readers with an emerging group of fungal infections that mostly manifest in immunocompetent individuals. This group was initially considered endemic to the tropics, but increasing worldwide prevalence has been reported. The organisms have been divided into dominant non-invasive forms and dominant invasive forms for ease of understanding.

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Objectives: To compare the effectiveness of two 5% sodium fluoride (NaF) varnishes containing casein phosphopeptide amorphous calcium phosphate (CPP-ACP) (MI Varnish) or tricalcium phosphate (TCP) (Clinpro White) to the conventional 5% NaF varnish (Duraphat®) in preventing early childhood caries (ECC) in high-risk preschool children.

Methods: A double-blinded, randomized controlled trial recruited healthy 3-4-year-old children (N = 582) having at least one carious lesion (pre-cavitated or cavitated) after obtaining written informed consent from parents. Using a computer-generated random-number table, children were assigned to one of the 3 groups: Control group (n = 196): 5% NaF varnish (Duraphat®) or two test groups: 5% NaF with TCP (Clinpro™ White) (n = 193) and 5% NaF varnish with CPP-ACP (MI Varnish™) (n = 193) to receive quarterly (every 3 months) application over 24 months.

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Article Synopsis
  • The study focuses on four cases of rare ectopic pregnancies occurring at the utero-tubal junction, highlighting the potential for severe maternal complications if these cases go undetected.
  • All four cases had different presentations, requiring distinct approaches for diagnosis, where initial 2D transvaginal scans were inadequate, and 3D transvaginal scans provided better localization of the gestational sacs.
  • The findings emphasized the importance of 3D imaging in managing these complex ectopic pregnancies and introduced a diagnostic algorithm and management strategies tailored to each case type.
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Background: Currently, the differentiation of jaw tumors is mainly based on the lesion's morphology rather than the enhancement characteristics, which are important in the differentiation of neoplasms across the body. There is a paucity of literature on the enhancement characteristics of jaw tumors. This is mainly because, even though computed tomography (CT) is used to evaluate these lesions, they are often imaged without intravenous contrast.

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Hypoglossal nerve stimulation is a treatment option for patients with obstructive sleep apnea who are intolerant to positive airway pressure therapy. In the post-implant period, awake endoscopy with advanced programming (AEAP) can be employed to optimize apnea-hypopnea index reduction and/or patient comfort and usage. The report herein describes awake endoscopy with AEAP as a guide to providers involved in post-implant care.

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Article Synopsis
  • - This study assessed how effective different MRI techniques (conventional diffusion weighted imaging, DKI, and IVIM) are in distinguishing between benign and malignant adnexal masses in 38 patients with 45 total masses.
  • - Findings showed that benign masses had significantly higher values for the mean apparent diffusion coefficient (ADC), D, and D, while malignant masses had higher values for the apparent kurtosis coefficient (K).
  • - The study concluded that while mean ADC, D, and K are useful for differentiating masses, IVIM and DKI did not provide additional benefits beyond what ADC offers in this context.
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The new 2023 update of the International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial cancer incorporates the advances made in the understanding of the pathology and molecular classifications into the staging system. While the new staging system aids in precision medicine and may lead to better documentation of prognostic risk categories of endometrial cancer, it is complex and calls for an integrated approach and better communication between multiple disciplines involved in the management of endometrial cancer. In this review article, we address how the referral patterns to imaging services might change considering the updated staging system for endometrial cancer.

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  • Vaginal pathologies are significant causes of genital tract symptoms in women and are often overlooked with standard transabdominal ultrasonography; transperineal USG and MRI are preferred for detailed evaluation.
  • Conditions affecting different age groups include congenital anomalies in children and young adults, such as vaginal septum and atresia, while adults commonly experience benign lesions and malignant tumors, like squamous cell carcinoma.
  • Understanding imaging features of these vaginal diseases is essential for proper diagnosis and treatment planning, particularly after interventions like radiotherapy, which alters the vagina's morphology.
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Compare the effectiveness of mesenchymal stem cell injection therapies (MSC) and thermal annular procedures for the treatment of discogenic lower back pain. A systematic review was performed following PRISMA 2020 guidelines. Pooled analysis was performed using patients' pain scores at baseline and at 12 months post-intervention.

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