Assessment of In-Vitro Synergy of Fosfomycin with Meropenem, Amikacin and Tigecycline in Whole Genome Sequenced Extended and Pan Drug Resistant : Exploring A Colistin Sparing Protocol.

Unlabelled: Fosfomycin has emerged as a very useful antimicrobial in management of extremely drug resistant (XDR) and pan drug resistant (PDR) . In this study, we assessed in-vitro synergy of colistin sparing combinations of fosfomycin (FOS) with meropenem (MEM), tigecycline (TGC) and amikacin (AK) against XDR and PDR .

Method: Non-replicate fully characterised 18 clinical isolates of (15 XDR and 3 PDR strains) were subjected to in-vitro synergy testing by checkerboard and time kill assay.