Publications by authors named "Manav T Daftari"
Article Synopsis
- The study examines how elevated amyloid beta (Aβ) levels are linked to cognitive issues in Alzheimer's disease and focuses on the role of the blood-brain barrier (BBB) in transferring Aβ to the brain.
- Researchers investigated how extracellular vesicles (EVs) from the brain's endothelium affect neural progenitor cells (NPCs) when exposed to Aβ, assessing changes in their mitochondrial functions and differentiation.
- Findings indicate that Aβ can indeed be transferred to NPCs via EVs, causing mitochondrial dysfunction and negatively impacting the NPCs' ability to develop into neurons, which has important implications for learning and memory in Alzheimer's disease.
While HIV-1 is primarily an infection of CD4 + T cells, there is an emerging interest towards understanding how infection of other cell types can contribute to HIV-associated comorbidities. For HIV-1 to cross from the blood stream into tissues, the virus must come in direct contact with the vascular endothelium, including pericytes that envelope vascular endothelial cells. Pericytes are multifunctional cells that have been recognized for their essential role in angiogenesis, vessel maintenance, and blood flow rate.
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