Publications by authors named "Manaswini Jagdeb"
Genomics Inform
June 2015
Article Synopsis
- Acute myeloid leukemia (AML) involves the abnormal growth of immature white blood cells and is regulated by micro RNAs (miRNAs) that interact with specific mRNAs and proteins like Argonaute (AGO).
- Researchers focused on the HOXA9 gene, known to be deregulated in AML, and selected four miRNAs (mir-145, mir-126, let-7a, and mir-196b) to target its mRNA.
- Computational studies revealed that mir-145 has the strongest binding affinity to the HOXA9 gene, and further analysis of miRNAs with AGO protein helped illuminate the gene silencing mechanisms involved in AML.
