Publications by authors named "Manasi Mohan"
Article Synopsis
- The study investigates real-world treatment practices and outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC) who have specific gene mutations related to DNA repair.
- Among 138 patients analyzed, common mutations included CDK12, BRCA2, and ATM; novel hormonal treatments and taxane chemotherapy were mainly used for first-line therapy, with survival rates declining in subsequent treatment lines.
- Findings suggest that treatment patterns for mCRPC patients are consistent with existing literature, regardless of the presence of homologous recombination repair (HRR) mutations.
Most shared resource flow cytometry facilities do not permit analysis of radioactive samples. We are investigating low-dose molecular targeted radionuclide therapy (MTRT) as an immunomodulator in combination with in situ tumor vaccines and need to analyze radioactive samples from MTRT-treated mice using flow cytometry. Further, the sudden shutdown of core facilities in response to the COVID-19 pandemic has created an unprecedented work stoppage.
View Article and Find Full Text PDFAn important component of research using animal models is ensuring rigor and reproducibility. This study was prompted after two experimenters performing virtually identical studies obtained different results when syngeneic B78 murine melanoma cells were implanted into the skin overlying the flank and treated with an in situ vaccine (ISV) immunotherapy. Although both experimenters thought they were using identical technique, we determined that one was implanting the tumors intradermally (ID) and the other was implanting them subcutaneously (SC).
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