Synthesis of π-Extended Benzofulvenes: A Pd-Catalyzed Cascade Annulation Process Comprising C-C Bond Formation Followed by 1,6-Conjugate Addition.

A Pd-catalyzed cascade annulation process comprising C-C bond formation followed by 1,6-conjugate addition for π-extended benzofulvenes is reported. This process is compatible with a wide range of functionalities for both the -quinone methides and internal alkynes, leading to diverse π-extended benzofulvenes. Additionally, this strategy is also applicable for aryne annulation with -quinone methides.

Substituted Isocoumarins: An Assemble of Synthetic Strategies Towards 3-Substituted and 3,4-Disubstituted Isocoumarins.

The versatility of isocoumarin frameworks offers the privilege to access many pharmacological targets. This unique heterocycle core present in many natural products and complex organic molecules contribute to medicinal chemistry as anti-cancer, anti-inflammatory and immunomodulatory agents. The attractive properties exhibited by its analogues urged the scientists to explore their synthetic analogues.

A Versatile Pd-Catalyzed Alkyne Annulation Process for Benzo[]carbazoles and their Anticancer Analogues.

A Pd-catalyzed, simple, and divergent approach for the direct synthesis of benzo[]carbazoles from internal alkynes and -tosyl-iodoindoles has been demonstrated. This methodology highlights the influences of reaction media and temperature for the synthesis of either N-protected or N-deprotected benzo[]carbazoles. This cascade strategy provides a series of electronically different benzo[]carbazoles with good yields.

Overview of coumarin-fused-coumarins: synthesis, photophysical properties and their applications.

Coumarin-fused-coumarins have attracted significant attention in the scientific world owing to their boundless applications in interdisciplinary areas. Various synthetic pathways have been developed to construct novel coumarin-fused-coumarin analogues by the fusion of modern methodologies with a classical Pechmann reaction or Knoevenagel condensation. Owing to their extended molecular framework, they possess interesting photophysical properties depending on the fused coumarin ring systems.

Exploration of Kobayashi's aryne precursor: a potent reactive platform for the synthesis of polycyclic aromatic hydrocarbons.

Arynes due to their transient nature leads to remarkable and versatile applications in the synthetic world. Apparently, researchers have focused on the construction of simple to complex π-conjugated systems using arynes as the reactive platform. In this regard, Kobayashi's aryne precursor has shown a great extent of reactivity and afforded significant advancement in the synthesis of polycyclic aromatic systems with wide practical utility.

Indane-Fused Spiropentadiene Chromanones: A Pd-Catalyzed Spiroannulation Followed by Cyclization C-H Activation Strategy.

Pd-catalyzed spiroannulation of 4-bromocoumarin with alkynes has been illustrated. The reaction highlights an interesting process for cascade formation of two five-membered rings through spiroannulation followed by cyclization C-H activation. This method offers an attractive platform for the synthesis of a broad range of indane-fused spiropentadiene chromanones in good yields.

Effect of Substrates on Catalytic Activity of Biogenic Palladium Nanoparticles in C-C Cross-Coupling Reactions.

This work describes a practical methodology for C-C bond formation reactions with the aid of biogenic palladium nanoparticles, which are synthesized by using phytochemicals extracted from two common plant species. Comparative studies have been done on the activity of two plant species ( and ) in generation of palladium nanoparticles via ex situ and in situ methods. The structural and morphological characteristics of the nanoparticles are examined by UV/visible spectroscopy, powder X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy analyses.

Greener Biogenic Approach for the Synthesis of Palladium Nanoparticles Using Papaya Peel: An Eco-Friendly Catalyst for C-C Coupling Reaction.

The development of a green and sustainable synthetic methodology still remains a challenge across the globe. Encouraging the prevailing challenge, herein, we have synthesized Pd nanoparticles (Pd NPs) in a green and environmentally viable route, using the extract of waste papaya peel without the assistance of any reducing agents, high-temperature calcination, and reduction procedures. The biomolecules present in the waste papaya peel extract reduced Pd(II) to nanosize Pd(0) in a one-pot green and sustainable process.