Publications by authors named "Manasa Mamunooru"

Herein, we disclose a facile synthetic strategy to access an important class of drug molecules that contain chiral 1,2-amino alcohol functionality utilizing highly effective ruthenium-catalyzed asymmetric transfer hydrogenation of unprotected α-ketoamines. Recently, the COVID-19 pandemic has caused a crisis of shortage of many important drugs, especially norepinephrine and epinephrine, for the treatment of anaphylaxis and hypotension because of the increased demand. Unfortunately, the existing technologies are not fulfilling the worldwide requirement due to the existing lengthy synthetic protocols that require additional protection and deprotection steps.

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We report a new class of highly effective, benzooxaphosphole-based, water-soluble ligands in the application of Suzuki-Miyaura cross-coupling reactions for sterically hindered substrates in aqueous media. The catalytic activities of the coupling reactions were greatly enhanced by the addition of catalytic amounts of organic phase transfer reagents, such as tetraglyme and tetrabutylammonium bromide. The optimized general protocol can be conducted with a low catalyst load, thereby providing a practical solution for these reactions.

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In this work, gradient elution isotachophoresis was combined with capillary zone electrophoresis (GEITP-CZE) in a single microcolumn. The multistage approach addresses the issues of analyte resolution difficulties in GEITP, as well as poor concentration sensitivity in CZE. GEITP employs rapid electrophoretic focusing at a discontinuous ionic interface within a sample well generated through combined electroosmotic and hydrodynamic flows.

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Article Synopsis
  • This study introduces a new technique called gradient elution isotachophoresis (GEITP) that improves the sensitivity of measurements by using a standard ultraviolet absorbance detector, making it accessible and versatile.
  • Various factors affecting enrichment, such as electrolyte concentration and electric field strength, were tested, leading to optimized conditions for separating the amino acids tryptophan and tyrosine.
  • The method achieved very low detection limits for the amino acids, with enhanced sensitivity and quick analysis times, demonstrating its potential for biochemical monitoring in complex samples like artificial cerebrospinal fluid.
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