Publications by authors named "Manas K Sinha"
Article Synopsis
- The Amur common carp, an important fish for aquaculture, has been improved through selective breeding, but its embryogenesis and immune gene expression are not well understood.
- A study examined the carp's embryonic development over approximately 44 hours, dividing it into eight distinct periods, with the segmentation stage showcasing significant developmental changes.
- Key immune-related genes displayed stage-specific expression patterns, with TLR4 peaking during the neurella stage, NOD1 and NOD2 during hatching, and IL-8 at the gastrula stage, marking the first report on this topic for Amur common carp.
Article Synopsis
- Cardiac surgery for coronary artery disease decreased significantly during the first COVID-19 pandemic wave, leading many patients to receive percutaneous coronary intervention (PCI) instead of the usual coronary artery bypass grafting (CABG).
- A study tracked 215 patients who underwent PCI, gathering 12-month outcomes like death, heart attacks, and other complications to evaluate the procedure's effectiveness.
- Results showed that after a year, PCI had acceptable outcomes with low rates of major adverse events, suggesting the need for further research comparing PCI to CABG in similar patient populations.
Objectives: To describe outcomes following percutaneous coronary intervention (PCI) in patients who would usually have undergone coronary artery bypass grafting (CABG).
Background: In the United Kingdom, cardiac surgery for coronary artery disease (CAD) was dramatically reduced during the first wave of the COVID-19 pandemic. Many patients with "surgical disease" instead underwent PCI.
Article Synopsis
- The study analyzed the success and complications of using excimer laser coronary atherectomy (ELCA) in patients experiencing balloon failure during percutaneous coronary intervention (PCI), with a focus on chronic total occlusions (CTO).
- Out of 58 identified balloon failure cases treated with ELCA, the overall procedure success rate was 91%, with ELCA used alone or in combination with rotational atherectomy (RA) showing favorable outcomes.
- The findings suggest that ELCA is a safe and effective option for treating difficult lesions in PCI, although there were some complications, including a serious incident leading to mortality.
The primary study aim was to determine whether ischemia-modified albumin (IMA) predicts adverse outcome in patients attending the emergency department (ED) with acute chest pain. Ischemia-modified albumin is a sensitive marker of myocardial ischemia. However, little is known about its ability to predict outcome in patients presenting to the ED with acute chest pain.
View Article and Find Full Text PDFBackground: Because of possible adverse outcomes, many of the >6 million annual emergency department (ED) patients with suspected acute coronary syndromes (ACS) undergo extensive evaluations. To minimize medical errors, chest pain evaluations are structured to identify accurately nearly 100% of patients with ACS. This is at a cost of negative evaluation rates that can exceed 90%.
View Article and Find Full Text PDFBackground: Ischemia modified albumin (IMA; Ischemia Technologies, Inc) blood levels rise in patients who develop ischemia during percutaneous coronary intervention (PCI). It is not known whether IMA elevations correlate with increases in other markers of oxidative stress, ie, 8-iso prostaglandin F2-A (iP).
Methods And Results: We compared IMA versus iP plasma levels in 19 patients (mean age 62.