Glutathione-S-transferase polymorphism and clinical features of acute drug poisoning in children.

We studied the association of GSTM1 and GSTT1 and GSTP1 Ile105-Val105 polymorphism with the duration of intoxication, polyorgan failure, and severity of drug poisoning in children. The combination of GSTM1 and GSTT1 zero genotypes is a favorable sign for the duration of intoxication and severity of the disease.

Activity of cytochrome P450 in children.

The 6beta-hydroxycortisol/cortisol ratio was measured in 52 children aging 1.1-14.0 years.

Interaction of GSTM1, GSTT1, and GSTP1 genotypes in determination of predisposition to atopic dermatitis.

The frequency of individual genotypes GSTM1, GSTT1, and GSTP1 and haplotypes was determined in patients with atopic dermatitis and healthy children. The actual frequency of some haplotypes was far below the theoretical value. Some haplotypes were associated with predisposition and resistance to atopic dermatitis.

Relationship between glutathione S-transferase P1 polymorphism and bronchial asthma and atopic dermatitis.

We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.

[Treatment of children with acute stenosing laryngotracheitis during prolonged tracheal intubation].

Therapy of acute decompensated forms of laryngotracheitis in children has not been well developed. The mortality rate as a result of asphyxia reaches 10 to 52%. The present authors were able to reduce significantly the number of hazardous complications and lethal outcomes when treating 32 children with acute decompensated forms of laryngotracheitis (only one patient died).