Diffusion-weighted magnetic resonance imaging of borderzone necrosis in paediatric tuberculous meningitis.

Purpose: Tuberculous meningitis (TBM) is associated with borderzone necrosis (BZN) of the brain parenchyma in areas adjacent to meningeal inflammation. Diffusion-weighted MRI (DWI) allows for accurate detection of cytotoxic oedema associated with necrosis. Detection and characterisation of BZN using DWI to explain its pathogenesis in TBM have not been performed previously in children.

Brainstem ischemic lesions on MRI in children with tuberculous meningitis: with diffusion weighted confirmation.

Introduction: The Western Cape in South Africa has one of the highest incidences of tuberculous meningitis (TBM) in the world. Despite therapy, the outcome in children with advanced TBM remains dismal. Magnetic resonance imaging (MRI) has been shown to be superior to computed tomography (CT) in demonstrating ischemia in TBM, especially of the brainstem.

MRI to demonstrate diagnostic features and complications of TBM not seen with CT.

Background: Computed tomography (CT) findings in children with tuberculous meningitis (TBM) often do not explain the clinical presentation and may even be normal. Magnetic resonance imaging (MRI) has the potential to diagnose TBM with greater sensitivity than CT and also to detect more infarcts.

Aim: The aim of this study was to determine whether MRI demonstrates features and complications of TBM not present on CT.

Magnetic resonance imaging of miliary tuberculosis of the central nervous system in children with tuberculous meningitis.

Background: Tuberculous meningitis (TBM) is closely associated with miliary tuberculosis and a pathogenetic relationship is suspected, although it has been proposed that the two processes are unrelated.

Objective: To describe miliary tuberculosis of the central nervous system (CNS) on MRI in children with TBM.

Materials And Methods: A retrospective descriptive study of 32 paediatric TBM patients referred for MRI.