Publications by authors named "Manami Masubuchi"
Article Synopsis
- - Various new circulating tumor cell (CTC) detection systems have been developed, but it remains challenging to surpass the prognostic value provided by the established CellSearch system in cancer diagnostics.
- - The researchers created a semi-automated system called FCMC, which can capture CTCs without relying on specific tumor markers, and they conducted a comparison between FCMC and CellSearch in breast cancer patients.
- - Results showed that FCMC had a statistically higher detection rate of certain cancer cells and a significantly greater number of CTCs detected in patient samples compared to CellSearch, with both systems showing potential as strong prognostic indicators for cancer progression.
A microfluidic reflectometric interference spectroscopy (RIfS) system was adopted for the investigation of protein-protein interaction (PPI). The influence of reaction conditions (pH and temperature) on the antigen-antibody reaction of alpha-fetoprotein (AFP) and its monoclonal antibody (anti-AFP) as a model of PPI was investigated in real time with a label-free fusion, where anti-AFP was covalently immobilized on the carboxylated silicon nitride sensor chips via amide bonds. Optimal pH and temperature were rapidly found by successive and alternate injections of AFP and the regeneration solution (glycine-HCl, pH 1.
View Article and Find Full Text PDFMolecular self-assemblies exhibiting automatic motions have received much attention as potential artificial models of living organisms. We have developed a microfluidic picolitre nozzle-array device to form multilamellar lipid tubes (MLTs) under fluidic shear stress, which transformed into different two patterns (yarn-balls and double-helixes) and also exhibited unique self-actuation behaviors.
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