Nattokinase, a Subtilisin-like Alkaline-Serine Protease, Reduces Mutacin Activity by Inactivating the Competence-Stimulating Peptide in .

is a major cariogenic organism because of its ability to form biofilms on tooth surfaces. Bacteriocins produced by (known as mutacins) are indirect pathogenic factors that play a role in the persistence of this microbe in the oral environment. Nattokinase, a subtilisin-like alkaline serine protease, potently inhibits biofilm formation without affecting growth.

Evaluation of Cellular Responses of Heterotrophic Cultured with Autotrophic as a Nutrient Source by Analyses Based on Microbiology and Transcriptome.

Heterotrophic microorganism LS5218 was cultured with flesh green alga C-9: NIES-2235 as a nutrient supplier. In order to evaluate the cell response of with , was evaluated with microbial methods and comprehensive gene transcriptional analyses. with showed a specific growth rate () of 1.

Investigation of Components in Roasted Green Tea That Inhibit Biofilm Formation.

form oral biofilms (BFs) and cause dental caries. Roasted green tea (RGT) is prepared by roasting the tea plant, and RGT-specific polyphenols are produced during the roasting process. Catechins, polyphenols in green tea, have BF inhibitory activity against ; therefore, RGT-specific polyphenols are also expected to have this activity.