Publications by authors named "Manami Kajiwara"
Many researchers have focused on the role of the autonomic nervous system in the tumor microenvironment. Autonomic nerves include the sympathetic and parasympathetic nerves, which are known to induce cancer growth and metastasis. However, in salivary duct carcinoma (SDC), a rare and highly malignant tumor, the issue should be investigated from both biological and therapeutic perspectives.
View Article and Find Full Text PDFHidrocystoma is thought to be a benign retention cyst of sweat ductal units. The lesion is usually located in the periorbital skin; however, lesions with similar histopathological features are rarely observed in extra-facial sites. Herein, we present four cases of hidrocystoma-like tumours in extra-facial skin sites that harboured a RET or ALK rearrangement.
View Article and Find Full Text PDFMesonephric-like adenocarcinoma (MLA) has recently been described as a tumor of the endometrium or ovaries, which, morphologically and immunohistochemically, resembles mesonephric adenocarcinoma arising mostly in the uterine cervix. Herein, we report, to our knowledge, the first case of ovarian MLA that developed into an extremely rapidly growing recurrent mesonephric-like carcinosarcoma, as confirmed by a genomic profiling test. A 51-year-old woman underwent chemotherapy with complete debulking surgery for ovarian carcinoma.
View Article and Find Full Text PDFArticle Synopsis
- Salivary duct carcinoma (SDC) is an aggressive salivary gland cancer, and recent advancements in immunotherapy targeting immune checkpoints (like PD1 and CTLA4) show promise for treatment.
- * The study analyzed 175 SDC cases, focusing on various immune markers and their correlation with tumor behavior, indicating that high levels of certain markers (CD8, PD-L1, etc.) relate to more aggressive cancer features and worse outcomes.
- * Interestingly, there were no cases with microsatellite instability (MSI-high), suggesting that a mix of immune activity in SDC may hinder effective T-cell function and highlight potential strategies for immune checkpoint combination therapies.*
Article Synopsis
- This study examined the characteristics of large cell neuroendocrine carcinoma (LCNEC) found in the skin and conjunctiva, focusing on a small group of patients with a median age of 85.
- The tumors were primarily located on the face, showed a high rate of metastasis, and had a significant risk of mortality, indicating their aggressive nature.
- Key findings included common immunoreactivity for various markers and the presence of mutant patterns for p53, PTEN, and Rb, suggesting potential challenges in diagnosis and treatment similar to other neuroendocrine tumors.
Objective: Salivary duct carcinoma (SDC) is a highly aggressive and uncommon tumor arising not only but also in pleomorphic adenoma. Androgen receptor (AR)- and HER2-targeted therapy have recently been introduced for SDC as promising treatment options; however, no predictive biomarkers have yet been established. EZH2 and H3K27me3 are closely linked to the development and progression of various cancers, and EZH2 is also expected to be a desirable therapeutic target.
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