Publications by authors named "Manami Endo"
Article Synopsis
- ALS is a progressive neurodegenerative disease characterized by the loss of motor neurons, showing increased levels of prostaglandin E2 (PGE2) in both ALS model mice and human patients.
- The study found that levels of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an enzyme involved in PGE2 metabolism, were significantly elevated in the lumbar spinal cord of ALS model mice during late disease stages.
- These findings suggest that the rise in PGE2 levels toward the end stage of ALS is due to a disruption in the balance between the production of PGE2 and its breakdown by 15-PGDH, contributing to disease progression.
Simple organic salts such as (Li(+))(m-IBA) (1), (Na(+))(m-IBA) (2), (K(+))(m-IBA) (3), (Rb(+))(m-IBA) (4), and (Cs(+))(m-IBA) (5) (m-IBA = m-iodobenzoate) were shown to form a mesophase before crystal melting or decomposition. The crystals were obtained in the hydrated form, e.g.
View Article and Find Full Text PDFProstaglandin E2 (PGE2) was shown to induce neuronal death in the CNS. To characterize the neurotoxicity of PGE2 and E-prostanoid receptors (EP) in motor neurons, we investigated PGE2-induced cell death and the type(s) of EP responsible for mediating it in NSC-34, a motor neuron-like cell line. Immunoblotting studies showed that EP2 and EP3 were dominantly expressed in NSC-34 cells and motor neurons in mice.
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