Publications by authors named "Manami Baba"
Article Synopsis
- RNA therapeutics show promise in targeting different biomolecules, but challenges like poor cancer selectivity and cell penetration have limited their effectiveness.
- Researchers developed a new oncolytic RNA hairpin pair designed to specifically kill cancer cells that express high levels of microRNA-21 (miR-21).
- This novel approach demonstrated that the hairpin RNA could act as a cytotoxic amplifier when activated by miR-21, marking a significant advance in RNA-based cancer treatment strategies.
Artificial nucleic acids have attracted much attention as potential cancer immunotherapeutic materials because they are recognized by a variety of extracellular and intracellular nucleic acid sensors and can stimulate innate immune responses. However, their low selectivity for cancer cells causes severe systemic immunotoxicity, making it difficult to use artificial nucleic acid molecules for immune cancer therapy. To address this challenge, we herein introduce a hairpin DNA assembly technology that enables cancer-selective immune activation to induce cytotoxicity.
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