Publications by authors named "Manali Garg"
Objectives: Bone marrow derived endothelial progenitor cells (BM-EPCs) are increased in chronic liver disease (CLD). Their role in hepatic fibrosis and regeneration remains an area of intense studies. We investigated the migration and secretory functions of BM-EPCs in fibrotic mice liver.
View Article and Find Full Text PDFSeveral microRNAs have been implicated in neurogenesis, neuronal differentiation, neurodevelopment, and memory. Development of miRNA-based therapeutics, however, needs tools for effective miRNA modulation, tissue-specific delivery, and in vivo evidence of functional effects following the knockdown of miRNA. Expression of miR-29a is reduced in patients and animal models of several neurodegenerative disorders, including Alzheimer's disease, Huntington's disease, and spinocerebellar ataxias.
View Article and Find Full Text PDFArticle Synopsis
- Nucleosome positioning maps reveal that Transcription Start Sites (TSSs) are characterized by a lack of nucleosomes, surrounded by well-positioned nucleosomes in various organisms.
- In mouse liver, most genes contain a notable nucleosome with the histone variant H2A.Z in their promoter regions, and clustering of genes is observed based on H2A.Z's distance from the TSS.
- Genes lacking H2A.Z show lower expression, while those with H2A.Z closer to the TSS exhibit higher expression levels, indicating that TSS accessibility and H2A.Z proximity influence gene expression.