Publications by authors named "Manal S Abd El Hamid"
Introduction: Liver cancer, particularly Hepatocellular carcinoma (HCC), remains a significant global health concern due to its high prevalence and heterogeneous nature. Despite the existence of approved drugs for HCC treatment, the scarcity of predictive biomarkers limits their effective utilization. Integrating diverse data types to revolutionize drug response prediction, ultimately enabling personalized HCC management.
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- The study investigates Nonalcoholic Steatohepatitis (NASH), a liver condition characterized by metabolic and inflammatory issues, with no current FDA-approved treatments available.
- Using machine learning, researchers analyzed NASH-induced rat models treated with various therapies to identify genetic and biochemical markers that predict treatment response, achieving up to 98.4% accuracy.
- Key findings reveal significant molecular features and biochemical markers associated with NASH improvement, emphasizing the potential of machine learning in developing noninvasive diagnostic methods.
Diabetic osteoporosis is a common health problem that is associated with a disruption in bone metabolism. A2A adenosine receptor (A2AAR) signaling seems to play a critical role in bone homeostasis. This study aimed to evaluate the effect of A2AAR stimulation on the treatment of diabetic-induced osteoporosis versus insulin treatment.
View Article and Find Full Text PDFQuercetin ameliorates acute lung injury in a rat model of hepatopulmonary syndrome.
BMC Complement Med Ther
December 2022
Background: Common bile duct ligation (BDL) is a rat experimental model to induce biliary cirrhosis. Lung fibrosis and pulmonary vascular angiogenesis and congestion are the most common complications of biliary cirrhosis that is known as hepatopulmonary syndrome. The aim of the present work is to investigate the acute lung injury in a BDL model and to investigate the possible protective effect of quercetin on this injury.
View Article and Find Full Text PDFBackground And Objectives: Bone marrow-derived mesenchymal stem cells (BM-MSCs) are adult multipotent non-haematopoietic stem cells that have regeneration potential. The current study aimed to detect the ability of BM-MSCs to improve kidney and cardiac functions in adult rats with established chronic kidney disease.
Methods: Rats were divided into sham-operated control, untreated sub totally nephrectomised and treated sub totally nephrectomised groups.