Calcium signaling in endocardial and epicardial ventricular myocytes from streptozotocin-induced diabetic rats.

Aims/introduction: Abnormalities in Ca signaling have a key role in hemodynamic dysfunction in diabetic heart. The purpose of this study was to explore the effects of streptozotocin (STZ)-induced diabetes on Ca signaling in epicardial (EPI) and endocardial (ENDO) cells of the left ventricle after 5-6 months of STZ injection.

Materials And Methods: Whole-cell patch clamp was used to measure the L-type Ca channel (LTCC) and Na /Ca exchanger currents.